Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia

Abstract

Carbon nanotubes (CNTs) are emerging versatile tools in nanomedicine applications, particularly in the field of cancer targeting. Due to diverse surface chemistry and unique thermal properties, CNTs can act as strong optical absorbers in near infrared light where biological systems prove to be highly transparent. The process of laser-mediated ablation of cancer cells marked with biofunctionalized CNTs is frequently termed “nanophotothermolysis.” This paper illustrates the potential of engineered CNTs as laser-activated photothermal agents for the selective nanophotothermolysis of cancer cells.

Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway

“…10 Because the physical properties of CNTs are essentially preserved by the noncovalent approach, aqueous solutions of CNTs 24 engineered by noncovalent functionalization are promising for multiple biomedical applications.…”

“…9 Carbon nanotubes (CNTs) have many unique physical, mechanical, electrical, and chemical properties, and have been intensively explored for biological and biomedical applications in the past few years. 10 Extensive reports have explored CNTs as potential drug carriers and delivery vehicles. [11][12][13][14][15] CNTs can be functionalized with pharmacologically active biomolecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions.…”

3-dimensional computer model of electrospinning multicapillary unit used for electrostatic field analysis

“…The distance between the capillaries was optimized using the mathematical modelling of the electrostatic field forming around the capillaries in the immediate vicinity of the others. The multicapillary stand allows to form the high oriented fleeces of fibres, what is possible because of a wide range of speed control of the spinning beam and the pickup drum [22].…”

Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes

“…19 CNTs promise an extraordinary combination of attributes in improving the next generation of photothermal agents because of their strong ability to transform NIR radiation into heat. 20 NIR exposure of CNTs excites electrons to the excited state and releases vibrational energy through heat, which could be used to induce cell death. 21,22 Studies show that CNTs can achieve thermal destruction using tenfold-lower doses in solution and using threefold-lower laser power than that required for gold nanorods, 23 and these also indicate that MWNTs are more potent than bulk single-walled nanotubes in transferring the NIR light into heat.…”