Advances in cellular and molecular pathways of salivary gland damage in Sjögren’s syndrome
Wenxia Qi,
Jiexiang Tian,
Gang Wang
et al.
Abstract:Sjögren’s Syndrome (SS) is an autoimmune disorder characterized by dysfunction of exocrine glands. Primarily affected are the salivary glands, which exhibit the most frequent pathological changes. The pathogenesis involves susceptibility genes, non-genetic factors such as infections, immune cells-including T and B cells, macrophage, dendritic cells, and salivary gland epithelial cells. Inflammatory mediators such as autoantibodies, cytokines, and chemokines also play a critical role. Key signaling pathways act… Show more
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