Advances in cervical cancer prevention: Efficacy, effectiveness, elimination?

Sundström, Karin; Elfström, K. Miriam

doi:10.1371/journal.pmed.1003035

Cited by 57 publications

(44 citation statements)

References 18 publications

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“…In gynecological oncology, the utility of prophylaxis and health-promoting behavior strategies can result in three outcomes: effective, leading to poor effects, or ineffective. Examples of the first outcome are vaccination and the application of effective screening tools in cervical cancer, with subsequent reduced morbidity and mortality [ 184 ]. Intermediate effective outcomes are achieved in endometrial cancer, where behaviors such as avoiding aggravating factors and following their effective treatment in co-morbid conditions (diabetes, hypertension, and obesity) reduced morbidity in some groups [ 185 ].…”

Section: Gynecological Cancersmentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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Diet and nutrition are fundamental in maintaining the general health of populations, including women’s health. Health status can be affected by nutrient deficiency and vice versa. Gene–nutrient interactions are important contributors to health management and disease prevention. Nutrition can alter gene expression, as well as the susceptibility to diseases, including cancer, through several mechanisms. Gynecological diseases in general are diseases involving the female reproductive system and include benign and malignant tumors, infections, and endocrine diseases. Benign diseases such as uterine fibroids and endometriosis are common, with a negative impact on women’s quality of life, while malignant tumors are among the most common cause of death in the recent years. In this comprehensive review article, a bibliographic search was performed for retrieving information about nutrients and how their deficiencies can be associated with gynecological diseases, namely polycystic ovary syndrome, infertility, uterine fibroids, endometriosis, dysmenorrhea, and infections, as well as cervical, endometrial, and ovarian cancers. Moreover, we discussed the potential beneficial impact of promising natural compounds and dietary supplements on alleviating these significant diseases.

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Section: Gynecological Cancersmentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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“…Cervical cancer trends mainly depend on the existence of effective screening programs, in conjunction with an HPV vaccination strategy. In the next decades, screening combined with vaccination are expected to eliminate cervical cancer in low-and middle-income countries, which hold the greatest burden of this cancer [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Time Trends Analysis of Cervical Cancer Incidence in Cluj County, Romania, Using Data from a Population-Based Cancer Registry

et al. 2021

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(1) Background: Romania has one of the highest cervical cancer incidence rates in Europe. In Cluj County, the first screening program was initiated in 1998. We aimed to investigate the time trends of cervical cancer incidence in women from Cluj County and to evaluate the data quality at the Cancer Registry. (2) Methods: We calculated time trends of standardized incidence rates in the period 1998–2014 and the Annual Percent Change (APC%). To assess data quality, we used the indicators: mortality/incidence ratio (M/I), percentage of cases declared only at death (DOD%), and percentage of cases with pathological confirmation (PC%). (3) Results: The standardized incidence rate increased steadily, from 23.74 cases/100,000 in 1998, to 32/100,000 in 2014, with an APC% of 2.49% (p < 0.05). The rise in incidence affected both squamous cell carcinoma (APC% 2.49%) (p < 0.05) and cervical adenocarcinoma (APC% 10.54%) (p < 0.05). The M/I ratio was 0.29, DOD% 2.66%, and MC% 94.8%. The last two parameters are within the silver standard concerning data quality. (4) Conclusions. Our study revealed an ascending trend of cervical cancer incidence, more consistent for adenocarcinoma, in the context of a newly introduced screening program and partially due to the improvement of the quality of case reporting at the Cancer Registry from Cluj.

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“…Cervical cancer is the fourth most common cancer among women globally, leading to an estimated 530,000 new cases and 270,000 deaths each year [ 1 , 2 ]. Screening and human papillomavirus (HPV) vaccination have remarkably reduced the incidence of cervical cancer in developed countries, but the application of both methods is restricted, and advanced cervical cancer is still very common in low-income countries [ 3 ], where approximately 90% of the world’s cervical cancer-related deaths occur [ 4 – 6 ]. The curative effect is not ideal, and the 5-year survival rate is only 16.7% in advanced cervical cancer patients [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression

Zhang

Zhao

Yang

et al. 2020

J Exp Clin Cancer Res

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Background Circular RNAs (circRNAs) have been reported to play key roles in the development of various cancers. However, the biological functions and clinical significance of most circRNAs are still elusive. The purpose of this study was to explore the function and mechanism of a certain circRNA named circCDKN2B-AS1 in cervical cancer development and its potential value in the clinic. Methods qRT-PCR was used to verify the expression level of circCDKN2B-AS1. CCK-8, Transwell, and flow cytometry (FCM) assays were performed to detect cellular proliferation, migration, and apoptosis, respectively. A Seahorse XFe96 Analyzer was used to measure glycolysis metabolism level. RNA pull-down, RNA immunoprecipitation (RIP), actinomycin-D addition assays and Western blotting were used to screen and elucidate the potential mechanisms involved. BALB/c nude mice and zebrafish embryos (AB, WT) were used as animal models to investigate tumorigenesis capability. 18FDG-microPET/CT imaging and lactic acid (LA) and pyruvic acid (PA) content detection assays were used to detect the level of glucose metabolism in subcutaneous tumors from nude mice. Results CircCDKN2B-AS1, a circular isoform of the long noncoding RNA (lncRNA) CDKN2B-AS1, was upregulated in cervical cancer and precancerous tissues. We found that circCDKN2B-AS1 associated with the IMP3 protein depending on a specific binding site and regulated the stability of Hexokinase 2 (HK2) mRNA, the rate-limiting enzyme of the aerobic glycolysis pathway. The expression level of circCDKN2B-AS1 fated the binding of IMP3 to the 3′ untranslated region (UTR) of HK2 mRNA, consequently affecting the malignant cell phenotype and aerobic glycolysis in cervical cancer in vitro and in vivo. Mutant circCDKN2B-AS1, lacking the IMP3 binding site, did not have such effects. Utilization of an inhibitory peptide to block the interaction between circCDKN2B-AS1 and the IMP3 protein impeded the binding of IMP3 to the 3’UTR of HK2 mRNA and suppressed aerobic glycolysis in cervical cancer cells. Conclusions Our findings demonstrate that circCDKN2B-AS1 facilitates aerobic glycolysis by sponging the IMP3 protein to stabilize HK2 mRNA, consequently promoting the malignant phenotype in cervical cancer, which may provide a potential approach for cervical cancer therapeutics.

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Advances in cervical cancer prevention: Efficacy, effectiveness, elimination?

Cited by 57 publications

References 18 publications

Nutrition in Gynecological Diseases: Current Perspectives

Nutrition in Gynecological Diseases: Current Perspectives

Time Trends Analysis of Cervical Cancer Incidence in Cluj County, Romania, Using Data from a Population-Based Cancer Registry

CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression

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