Advances in chromone-based copper(<scp>ii</scp>) Schiff base complexes: synthesis, characterization, and versatile applications in pharmacology and biomimetic catalysis

Kumar, Sumit; Arora, Aditi; Maikhuri, Vipin K.; Chaudhary, Ankita; Kumar, Rajesh; Parmar, Virinder S.; Singh, Brajendra K.; Mathur, Divya

doi:10.1039/d4ra00590b

RSC Adv.

2024

DOI: 10.1039/d4ra00590b

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Advances in chromone-based copper(ii) Schiff base complexes: synthesis, characterization, and versatile applications in pharmacology and biomimetic catalysis

Sumit Kumar,

Aditi Arora,

Vipin K. Maikhuri

et al.

Abstract: Chromones are well known as fundamental structural elements found in numerous natural compounds and medicinal substances.

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Cited by 5 publications

References 131 publications

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New Metal Complexes Incorporating Schiff Base Ligand Based on Pyridine Moiety: Synthesis, Spectral Characterization, DFT, Biological Evaluation, and Molecular Docking

Salah,

Adly,

Ibrahim

et al. 2024

Applied Organom Chemis

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A new Schiff base ligand, HNMPC, was prepared and reacted with some metal ions, including Cu(II), Ni(II), Co(II), Mn(II), and VO(IV). The infrared, electronic, mass, electron spin resonance, nuclear magnetic resonance, thermal and elemental analysis, molar conductance, and magnetic susceptibility measurements were used to characterize the metal complexes. The HNMPC ligand acts as a monoanionic tridentate ONO donor in all complexes, and the coordinating sites are C=Opyridone, C=N, and the phenolate anion. All metal complexes exhibit octahedral configurations, and the results showed that the metal ion:ligand ratio was 1:2. The molecular structural parameters of the ligand and its metal complexes were determined based on the DFT level implemented in the Gaussian 09 program B3LYP/GENECP method at the 6‐311G(d,p) basis set for C, H, N, and O atoms and the SDD (Stuttgart/Dresden) basis set for the metal atoms. The theoretical data were correlated with the experimental results. Gram‐positive bacteria, Gram‐negative bacteria, yeast, and fungi were used to test the current compounds' antimicrobial activity. Investigating the antitumor activity of the ligand and its complexes against the HepG2 cell lines showed encouraging IC50 values that were on par with those of cisplatin. In order to determine the affinity and binding pattern for the synthesized compounds toward the VEGFR‐2 active site, molecular docking studies were conducted, and the results were correlated with antitumor data. Based on the obtained results, future work aimed to synthesize a new category of Schiff bases and their metal complexes derived from the current aminopyridine derivative with diverse aldehydes and ketones.

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New Metal Complexes Incorporating Schiff Base Ligand Based on Pyridine Moiety: Synthesis, Spectral Characterization, DFT, Biological Evaluation, and Molecular Docking

Salah,

Adly,

Ibrahim

et al. 2024

Applied Organom Chemis

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Exploring the utilization of Schiff base metal complexes in biological settings: A review

Rajan Arun,

Phani Kumar,

Kamalesu

2024

Inorganic Chemistry Communications

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Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

Leitão,

Morais

2024

J. Med. Chem.

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Innovative strategies for targeted anticancer therapies have gained significant momentum, with metal complexes emerging as tunable catalysts for more effective and safer treatments. Rational design and engineering of metal complexes enable the development of tailored molecular structures optimized for precision oncology. The strategic incorporation of metal complex catalysts within combinatorial therapies amplifies their anticancer properties. This perspective highlights the advancements in synthetic strategies and rational design since 2019, showing how tailored metal catalysts are optimized by designing structures to release or in situ synthesize active drugs, leveraging the target-specific characteristics to develop more precise cancer therapies. This review explores metal-based catalysts, including those conjugated with biomolecules, nanostructures, and metal−organic frameworks (MOFs), highlighting their catalytic activity in biological environments and their in vitro/in vivo performance. To sum up, the potential of metal complexes as catalysts to reshape the landscape of anticancer therapies and foster novel avenues for therapeutic advancement is emphasized. ■ SIGNIFICANCE• Metal complexes have been strategically engineered for precision oncology, offering an enhanced efficacy with reduced side effects. • Rational design and engineering of metal complexes enables the creation of customized molecular structures that release or synthesize active drugs directly at the target site, enhancing the precision of oncology treatments. • Cutting-edge strategies and advancements in drug design that combine metal complexes with advanced catalysis techniques to develop more effective and targeted anticancer drugs are presented.

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Advances in chromone-based copper(ii) Schiff base complexes: synthesis, characterization, and versatile applications in pharmacology and biomimetic catalysis

Abstract: Chromones are well known as fundamental structural elements found in numerous natural compounds and medicinal substances.

Cited by 5 publications

References 131 publications

New Metal Complexes Incorporating Schiff Base Ligand Based on Pyridine Moiety: Synthesis, Spectral Characterization, DFT, Biological Evaluation, and Molecular Docking

New Metal Complexes Incorporating Schiff Base Ligand Based on Pyridine Moiety: Synthesis, Spectral Characterization, DFT, Biological Evaluation, and Molecular Docking

Exploring the utilization of Schiff base metal complexes in biological settings: A review

Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

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