2023
DOI: 10.3390/app13084924
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Advances in Chronic Kidney Disease in Africa

Abstract: Africa, particularly sub-Sharan Africa (SSA), faces major challenges in respect to chronic kidney disease (CKD). There is a rising prevalence due to the combined effects of hypertension, diabetes, and human immunodeficiency virus (HIV) (and the interaction between them) and the effect of apolipoprotein L1 (APOL1) variants on the susceptibility to CKD. Epidemiological data on the prevalence of CKD are of low-to-medium quality, and reliable data are urgently needed for health planning. Furthermore, there are imp… Show more

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“…Furthermore, there are significant deficiencies in creatinine-based equations for estimating CKD prevalence in African populations. The review highlights several key advances in understanding CKD in Africa, particularly regarding hypertension, diabetes, HIV, CKD of unknown etiology (CKDu), and the long-term effects of hypertension in pregnancy and pregnancy-related acute kidney injury (PRAKI) [12]. Addressing these challenges requires tailored interventions and improved diagnostic methods to enhance CKD management in SSA.…”
mentioning
confidence: 99%
“…Furthermore, there are significant deficiencies in creatinine-based equations for estimating CKD prevalence in African populations. The review highlights several key advances in understanding CKD in Africa, particularly regarding hypertension, diabetes, HIV, CKD of unknown etiology (CKDu), and the long-term effects of hypertension in pregnancy and pregnancy-related acute kidney injury (PRAKI) [12]. Addressing these challenges requires tailored interventions and improved diagnostic methods to enhance CKD management in SSA.…”
mentioning
confidence: 99%