Advances in computational methods along the exposure to toxicological response paradigm

El‐Masri, Hisham A.; Friedman, Katie Paul; Isaacs, Kristin; Wetmore, Barbara A.

doi:10.1016/j.taap.2022.116141

Cited by 5 publications

(1 citation statement)

References 172 publications

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“…Transcriptomic biomarkers can identify early molecular changes or molecular initiating events associated with different adverse outcome pathways (AOP) (El-Masri et al, 2022). Thus far, there are three AOPs in the AOPWiki (https://aopwiki.org) that are initiated by HDACi: one of these is endorsed by the Organisation for Economic Cooperation and Development (OECD) and leads to testicular atrophy (https://aopwiki.org/aops/212) (Tanabe et al, 2021); two others that are in development lead to impairments in craniofacial development and neural tube defects.…”

Section: Introductionmentioning

confidence: 99%

Application of Genomics-Based Methodologies in Genetic Toxicology to Advance In Vitro Chemical Assessment

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ICHInternational Council for Harmonisation ICCVAM Interagency Coordinating Committee on the Validation of Alternative Methods KEKey event KER Key event relationship MF Mutation frequency MIE Molecular initiating event MN Micronucleus MOA Mode of action NAM New Approach Methodology NER Nucleotide excision repair NGS Next-generation sequencing NSC Nearest shrunken centroid NTP National Toxicology Program OECD Organization for Economic Co-operation and Development RT-qPCR Real Time Quantitative Polymerase Chain Reaction QSAR Quantitative Structure-Activity Relationship PA Probability analysis PCA Prinicipal component analysis ROS Reactive oxygen species RS Relative survival TempO-Seq Templated Oligo-Sequencing TGR Transgenic rodent TGx Toxicogenomics TSA Trichostain A VPA Valproic acid xvi Statement of Contributions Chapter 2: Assessment of the performance of the TGx-DDI biomarker to detect DNA damage-inducing agents using quantitative RT-PCR in TK6 cells

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Section: Introductionmentioning

confidence: 99%

Application of Genomics-Based Methodologies in Genetic Toxicology to Advance In Vitro Chemical Assessment

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Private, public, and bottled drinking water: Shared contaminant-mixture exposures and effects challenge

Bradley,

Romanok,

Smalling

et al. 2025

Environment International

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Probing the bioconcentration and metabolism disruption of bisphenol A and its analogues in adult female zebrafish from integrated AutoQSAR and metabolomics studies

Chen,

Hu,

Chen

et al. 2023

Science of The Total Environment

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Advances in computational methods along the exposure to toxicological response paradigm

Cited by 5 publications

References 172 publications

Application of Genomics-Based Methodologies in Genetic Toxicology to Advance In Vitro Chemical Assessment

Application of Genomics-Based Methodologies in Genetic Toxicology to Advance In Vitro Chemical Assessment

Private, public, and bottled drinking water: Shared contaminant-mixture exposures and effects challenge

Probing the bioconcentration and metabolism disruption of bisphenol A and its analogues in adult female zebrafish from integrated AutoQSAR and metabolomics studies

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