Advances in Copper-Based Biomaterials With Antibacterial and Osteogenic Properties for Bone Tissue Engineering

Abstract

Treating bone defects coupled with pathogen infections poses a formidable challenge to clinical medicine. Thus, there is an urgent need to develop orthopedic implants that provide excellent antibacterial and osteogenic properties. Of the various types, copper-based biomaterials capable of both regenerating bone and fighting infections are an effective therapeutic strategy for bone tissue engineering and therefore have attracted significant research interest. This review examines the advantages of copper-based biomaterials for biological functions and introduces these materials’ antibacterial mechanisms. We summarize current knowledge about the application of copper-based biomaterials with antimicrobial and osteogenic properties in the prevention and treatment of bone infection and discuss their potential uses in the field of orthopedics. By examining both broad and in-depth research, this review functions as a practical guide to developing copper-based biomaterials and offers directions for possible future work.

Microporous surface containing flower-like molybdenum disulfide submicro-spheres of sulfonated polyimide with antibacterial effect and promoting bone regeneration and osteointegration

“…Therefore, efforts are required to produce implants with antibacterial functions that reduce infection in orthopedics. 39 Due to its having no osteogenic activity, PI is incapable of forming an integration with host bone, which may increase the possibility of bacteria entering the micro-environment at the interface of the implant and bone, which potentially induces infection. 40 In this study, PI showed no antibacterial effect while SPM0 exhibited low antibacterial effect due to the presence of –SO 3 H groups with low antibacterial effect.…”

Biomimetic Antibacterial Pro-Osteogenic Cu-Sericin MOFs for Osteomyelitis Treatment

“…The latest advances in copper (Cu)-based biomaterials with osteogenic and antibacterial properties in bone tissue engineering have been illustrated well by Shen et al [ 21 ]. According to the comprehensive review, adding Cu to complex hydroxyapatite-containing materials results in better bone substitutes.…”

Mechanochemical Preparation, Solid-State Characterization, and Antimicrobial Performance of Copper and Silver Nitrate Coordination Polymers with L- and DL-Arginine and Histidine

“…It is worth recalling that silver is presently widely used in wound dressings and medical devices because it exerts broad-spectrum antimicrobial activity against Gram-positive and -negative bacteria, viruses, fungi, and protozoa [ 20 , 21 ], while copper is an esteemed antimicrobial agent and has long been used for its medical properties [ 22 , 23 ]. Nowadays, copper is widely studied in different forms and formulations for the antimicrobial treatment of surfaces [ 24 , 25 ] and on medical devices and implants [ 26 , 27 ]. We can find various examples of copper used in its metallic state [ 28 , 29 , 30 ], in a nanoparticle form [ 31 ], and as a coordination compound or ionic co-crystal [ 32 , 33 , 34 ].…”