Within the engineering domain, safety issues are often related to engineering design and typically exclude factors such as epidemics, famine, and disease. This article provides a perspective on the reciprocal relationship and interaction between a natural hazard and a simultaneous pandemic outbreak and discusses how a catastrophic dam break, combined with the ongoing COVID-19 pandemic, poses a risk to human life. The paper uses grey- and peer-reviewed literature to support the discussion and reviews fundamentals of dam safety management, potential loss of life due to a dam break, and the recent evolution in dam risk analysis to account for the COVID-19 outbreak. Conventional risk reduction recommendations, such as quick evacuation and sheltering in communal centers, are revisited in the presence of a pandemic when social distancing is recommended. This perspective manuscript aims to provide insight into the multi-hazard risk problem resulting from a concurring natural hazard and global pandemic.