Advances in Diagnosis and Pathophysiology of Microvascular Dysfunction

Jan, Yih‐Kuen

doi:10.3390/diagnostics12030620

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…The state of microvascular bed of skin and mucous membranes reflects both as the organ-specific features of blood flow well as changes occurring in microvascular system of the whole organism [ 9 – 12 ]. Changes in skin microvascular system correlate with shifts in central hemodynamics, which makes it possible to use the parameters of blood microcirculation in skin as diagnostic and prognostic markers to assess the health and general physical state of an organism [ 4 , 11 – 14 ].…”

Section: Study Of Peripheral Hemodynamics and Analysis Of Skin Blood ...mentioning

confidence: 99%

Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus

et al. 2022

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The review presents modern ideas about peripheral microhemodynamics, approaches to the ana-lysis of skin blood flow oscillations and their diagnostic significance. Disorders of skin microhemodynamics in type 2 diabetes mellitus (DM) and the possibility of their interpretation from the standpoint of external and internal interactions between systems of skin blood flow regulation, based on a comparison of couplings in normal and pathological conditions, including models of pathologies on animals, are considered. The factors and mechanisms of vasomotor regulation, among them receptors and signaling events in endothelial and smooth muscle cells considered as models of microvessels are discussed. Attention was drawn to the disturbance of Ca 2+ -dependent regulation of coupling between vascular cells and NO-dependent regulation of vasodilation in diabetes mellitus. The main mechanisms of insulin resistance in type 2 DM are considered to be a defect in the number of insulin receptors and impaired signal transduction from the receptor to phosphatidylinositol-3-kinase and downstream targets. Reactive oxygen species plays an important role in vascular dysfunction in hyperglycemia. It is assumed that the considered molecular and cellular mechanisms of microhemodynamics regulation are involved in the formation of skin blood flow oscillations. Parameters of skin blood microcirculation can be used as diagnostic and prognostic markers for assessing the state of the body.

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Section: Study Of Peripheral Hemodynamics and Analysis Of Skin Blood ...mentioning

confidence: 99%

Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus

et al. 2022

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Analysis of Oscillatory Processes in the Cardiovascular System in Response to Local Heating in Patients with Type 2 Diabetes Mellitus

Tikhonova,

Tankanag,

Guseva

et al. 2023

BIOPHYSICS

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Analysis of oscillatory processes in the cardiovascular system in response to local heating in patients with type 2 diabetes mellitus

Tikhonova,

Tankanag,

Guseva

et al. 2023

Biofizika

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A comprehensive spectral analysis was used to assess heart rate variability and skin perfusion pattern of limbs in patients with type 2 diabetes mellitus in response to local heating and to identify significant predictors of physiological and pathological changes in the cardiovascular system. An electrocardiogram and skin perfusion on the forearm and foot were measured using Laser Doppler flowmetry at rest and during local heating in both healthy volunteers and patients with type 2 diabetes. The wavelet analysis was applied to Laser Doppler signals and heart rate variability (based on electrocardiogram signals). ROC analysis was used to evaluate significant predictors. The analysis results of patients with type 2 diabetes were compared with healthy controls. The following changes were observed in patients 1) impairment of skin blood flow reserve on the foot during heating, 2) lower amplitude oscillations in heart rate at rest and during heating, 3) an increase in amplitude of oscillations in the skin blood flow from the forearm in intervals related to respiration and heart activity at rest and during heating, 4) a decrease in amplitude of oscillations in the skin blood flow on the foot in the interval related to myogenic activity at rest and in cardiointerval during heating. The parameters of cardiovascular system (energies of heart rate variability at low-frequencies recorded by laser Doppler flowmetry on forearm in intervals related to respiration activity) with high discriminative power were revealed to distinguish patients from healthy subjects in response to local heating; these parameters can be used as markers for early diagnosis of microvascular disorders.

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Advances in Diagnosis and Pathophysiology of Microvascular Dysfunction

Abstract: Microcirculation is the system that brings oxygen and nutrients to local cells and removes metabolic wastes [...]

Cited by 3 publications

References 10 publications

Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus

Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus

Analysis of Oscillatory Processes in the Cardiovascular System in Response to Local Heating in Patients with Type 2 Diabetes Mellitus

Analysis of oscillatory processes in the cardiovascular system in response to local heating in patients with type 2 diabetes mellitus

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