Advances in Dietary Phenolic Compounds to Improve Chemosensitivity of Anticancer Drugs

Abstract

Despite the significant advances and mechanistic understanding of tumor processes, therapeutic agents against different types of cancer still have a high rate of recurrence associated with the development of resistance by tumor cells. This chemoresistance involves several mechanisms, including the programming of glucose metabolism, mitochondrial damage, and lysosome dysfunction. However, combining several anticancer agents can decrease resistance and increase therapeutic efficacy. Furthermore, this treatment can improve the effectiveness of chemotherapy. This work focuses on the recent advances in using natural bioactive molecules derived from phenolic compounds isolated from medicinal plants to sensitize cancer cells towards chemotherapeutic agents and their application in combination with conventional anticancer drugs. Dietary phenolic compounds such as resveratrol, gallic acid, caffeic acid, rosmarinic acid, sinapic acid, and curcumin exhibit remarkable anticancer activities through sub-cellular, cellular, and molecular mechanisms. These compounds have recently revealed their capacity to increase the sensitivity of different human cancers to the used chemotherapeutic drugs. Moreover, they can increase the effectiveness and improve the therapeutic index of some used chemotherapeutic agents. The involved mechanisms are complex and stochastic, and involve different signaling pathways in cancer checkpoints, including reactive oxygen species signaling pathways in mitochondria, autophagy-related pathways, proteasome oncogene degradation, and epigenetic perturbations.

Charting the Cannabis plant chemical space with computational metabolomics

“…Other polyphenolic compounds such as feruloyl quinic acid and caffeoylquinic acid reported in Table S1 were also detected in the leaves. These phenolic acids which form part of chlorogenic acids are known to possess anticarcinogenic properties due to their antioxidant activities (Makhafola et al, 2016; Bouyahya et al, 2022). When evaluating the superclasses present in the flowers of the two cutivars, the Phenylpropanoids and polyketide superclass (comprised of polyphenolic compounds) was less dominant.…”

Charting the Cannabis plant chemical space with computational metabolomics

“…Other polyphenolic compounds such as feruloyl quinic acid and caffeoylquinic acid reported in Table S1 were also detected in the leaves. These phenolic acids which form part of chlorogenic acids are known to possess anticarcinogenic properties due to their antioxidant activities (Makhafola et al, 2016 ; Bouyahya et al, 2022 ). When evaluating the superclasses present in the flowers of the two cutivars, the Phenylpropanoids and polyketide superclass (comprised of polyphenolic compounds) was less dominant.…”

Medicago sativa Extracts Enhance the Anticancer Efficacy of GEM in PANC-1 Cells through Apoptosis Induction and BAX/BCL-2/CASP3 Expression Modulation

“…NPs are gaining popularity in cancer treatment because they have fewer side effects, are less costly, and are more easily accessible than popular medications. A lecture through a published research review by Bouyahya et al, [41] showed that phenolic compounds are great sources of naturally occurring anticancer agents, offering various therapeutic and preventive options for the treatment of numerous cancer types. These chemicals can be employed solely or in conjunction with currently available anticancer medicines.…”