Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications

Afewerki, Samson; Bassous, Nicole; Harb, Samarah Vargas; Palo‐Nieto, Carlos; Ruiz–Esparza, Guillermo U.; Marciano, Fernanda R.; Webster, Thomas J.; Furtado, André Sales Aguiar; Lobo, Anderson Oliveira

doi:10.1016/j.nano.2019.102143

Cited by 61 publications

(44 citation statements)

References 176 publications

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“…Fundamental aspects in this group of ceramics are firstly their “smart” capacity to adapt and modify their properties to the changing implant site environment, and secondly, a diverse handling method, mostly at room temperature, that allow the inclusion and preservation of bioactive molecules (drugs/antibiotics, growth factors, magnetic particles for thermal cancer therapy) ( Vallet-Regi et al, 2012 ; Comesaña et al, 2015 ; Koju et al, 2018 ; Vallet-Regí and Salinas, 2019 ). With the purpose to obtain enhanced therapeutic effectiveness, these materials were therefore tested in many studies as drug carriers or as gene delivery systems ( Ruiz-Hernández et al, 2008 ; Liu et al, 2009 ; Vallet-Regí and Ruiz-Hernández, 2011 ; Wu and Chang, 2014 ; Gao et al, 2015 ; Santos et al, 2017 ; Köse et al, 2018 ; Afewerki et al, 2020 ). To better resemble natural bone apatite and interact with neighbor tissues, synthetic HA can include several diverse ions in place of Ca 2+ , PO 4 3– , or OH – , e.g., Na + , K + , Mg 2+, Sr 2+ , Zn 2+ , Cl – , F – , HPO 4 2– ( Kim et al, 1998 ; Vallet-Regí and Arcos, 2005 ; Landi et al, 2007 , 2008 ; Kolmas et al, 2011 ; Bornapour et al, 2013 ; Montesi et al, 2017 ; Arcos and Vallet-Regí, 2020 ).…”

Section: Biomaterials For Bone Tissue Applicationsmentioning

confidence: 99%

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Guerrieri

Montesi

Sprio

et al. 2020

Front. Bioeng. Biotechnol.

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Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.

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Section: Biomaterials For Bone Tissue Applicationsmentioning

confidence: 99%

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Guerrieri

Montesi

Sprio

et al. 2020

Front. Bioeng. Biotechnol.

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“…In recent decades, the progress in bioorganic, inorganic, organic and polymer chemistry resulted in the creation of efficient interdisciplinary techniques proposed for bone treatment, including efficient bone substitution and repair after ‘critical-sized’ bone damage caused by trauma, surgery or infection [ 1 , 2 , 3 , 4 , 5 ]. The desired characteristics of the materials for bone substitution and repair are biocompatibility, osteoinductivity and osteoconductivity, sufficient mechanical strength and antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Poly(ε-CL)/Hydroxyapatite Electrospun Fibers Reinforced by Poly(ε-CL)-b-poly(ethylene phosphoric acid)

Nifant’ev

Gavrilov

Tavtorkin

et al. 2021

IJMS

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In bone surgery and orthopedics, bioresorbable materials can be helpful in bone repair and countering post-op infections. Explicit antibacterial activity, osteoinductive and osteoconductive effects are essential to achieving this objective. Nonwoven electrospun (ES) fibers are receiving the close attention of physicians as promising materials for wound dressing and tissue engineering; potentially, in high contrast with dense materials, ES mats hamper regeneration of the bone extracellular matrix to a lesser extent. The use of the compositions of inherently biodegradable polyesters (poly(ε-caprolactone) PCL, poly(lactoglycolide), etc.), calcium phosphates and antibiotics is highly prospective, but the task of forming ES fibers from such compositions is complicated by the incompatibility of the main organic and inorganic ingredients, polyesters and calcium phosphates. In the present research we report the synthesis of hydroxyapatite (HAp) nanoparticles with uniform morphology, and demonstrate high efficiency of the block copolymer of PCL and poly(ethylene phosphoric acid) (PEPA) as an efficient compatibilizer for PCL/HAp mixtures that are able to form ES fibers with improved mechanical characteristics. The materials obtained in the presence of vancomycin exhibited incremental drug release against Staphylococcus aureus (St. aureus).

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“…Despite the ongoing development of bone tissue engineering, the occurrence of infections remains very common and has become one of the main causes of bone graft failure. For example, initial bacterial contamination occurs in 78.7% of cases of open fractures, which results in a mean bone infection rate of 10.2%, and the failure of 10 -20% of cases in surgery for mandible bone grafts is caused by infection [1][2][3] . Orthopedic infection caused by bacterial colonization could cause prolonged hospital stays, unsatisfactory functional outcomes, and increased patient dissatisfaction; however, their treatment is still a clinical challenge 3) .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and pro-osteogenic effects of β-Defensin-2-loaded mesoporous bioglass

et al. 2021

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The human antimicrobial peptide beta-defensin-2 (hBD2) shows broad antibacterial activity and infrequent bacterial resistance. Here mesoporous bioactive glass (MBG) was loaded with hBD2, forming hBD2-loaded MBG (BD-MBG). The antibacterial and osteogenic effects of BD-MBG were investigated in comparison with MBG and the blank control (BC). The result showed that BD-MBG yielded sustained hBD2 release for more than 7 weeks in vitro, and resulted in significantly lower amounts of viable bacteria and colony forming units, and significantly higher levels of bacterial protein release compared with those in the BC and MBG groups (all p<0.05). Compared with that in the BC group, significantly higher bone marrow stromal cell (BMSC) proliferation rates, alkaline phosphatase (ALP) activity, calcium nodule formation, and expression levels of early and late osteogenic makers were observed after MBG and BD-MBG treatments (p<0.05). Thus, BD-MBG inhibited bacterial growth, damaged their membrane, and promoted early and late osteogenic BMSC differentiation.

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Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications

Cited by 61 publications

References 176 publications

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Antibacterial Poly(ε-CL)/Hydroxyapatite Electrospun Fibers Reinforced by Poly(ε-CL)-b-poly(ethylene phosphoric acid)

Antibacterial and pro-osteogenic effects of β-Defensin-2-loaded mesoporous bioglass

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