Advances in early biomarkers of diabetic nephropathy

Zhang, Jin; Liu, Jianhua; Qin, Xiaosong

doi:10.1590/1806-9282.64.01.85

Cited by 60 publications

(46 citation statements)

References 59 publications

(62 reference statements)

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“…Diabetic Nephropathy DN, as a chronic complication of diabetes, is a main cause of end-stage kidney disease (Flyvbjerg, 2017;Zhang J. et al, 2018), which occurs in patients with DM, and reduced kidney function involved in hyperglycemia-induced renal hyper filtration and injury, AGE-induced increased OS, activated protein kinase C (PKC)-induced increased production of cytokines, chemokines, and different inflammatory and apoptotic signals (Bhattacharjee et al, 2016). Detachment of podocytes from the glomerular basement membrane is also considered a key factor in the development of DN (Sawada et al, 2016).…”

Section: Chronic Complicationsmentioning

confidence: 99%

Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Jiang

Meng

et al. 2020

Front. Pharmacol.

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Background: Diabetic complications seriously endanger the health of most diabetic patients around the world. Most chemical hypoglycemic agents have adverse effects and are unable to improve the progression of diabetic complications. In recent years, a number of medicinal herbs have become increasingly popular for the treatment of diabetic complications due to their relative safety. Polysaccharides extracted from medicinal herbs with multiple pharmacological activities and low toxicity have been reported to be useful in the treatment of diabetic complications. Methods: Primary studies with keywords including polysaccharide and diabetic complications were retrieved from the Web of Science and NCBI databases and were read and analyzed. Results: Mushroom polysaccharides were proven to have positive effects on diabetic complications. Conclusions: We studied the effects of mushroom polysaccharides on hyperglycemia and as adjuvant therapies for diabetic complications and summarized the applications and limitations of mushroom polysaccharides to better understand their application for the treatment of diabetic complications.

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Section: Chronic Complicationsmentioning

confidence: 99%

Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Jiang

Meng

et al. 2020

Front. Pharmacol.

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“…Abnormalities in the lipid metabolism pathway, activation of the renin-angiotensin-aldosterone system (RAAS), as well as systemic and glomerular hypertension are also involved in the progression of this disease. Impairment of insulin signaling, an increase in growth factors and proinflammatory cytokines, and activation of the intracellular signaling pathway also play a role in the development of this disease [157]. Therefore, the currently known DN biomarkers focus on three areas: Detection of oxidative stress, the occurrence of inflammation, and activation of the RAAS system (Figure 8).…”

Section: Diabetic Nephropathy (Dn)mentioning

confidence: 99%

“…Biomarkers associated with diabetic nephropathy pathogenesis (based on[157]). 8-OHdG-8-hydroxy-2'-deoxyguanine; AOPP-advanced oxidation protein product; CHIT1-chitotriosidase; DNPH-2,4-dinitrophenylhydrazine; GS-Glutathione s-transferase; HNE-4-hydroxy-nonenal; IL-6-interleukin 6; IL-8-interleukin 8; IL-18-interleukin 18; IP-10-interferon-inducible protein-10; MCP-1-Monocyte chemoattractant protein-1; MDA-malondialdehyde; sCD40L-soluble CD40 ligand; TNF-α-Tumor necrosis factor alpha; YKL-40-cartilage glycoprotein 40.…”

mentioning

confidence: 99%

Toll-Like Receptor as a Potential Biomarker in Renal Diseases

Mertowski

Lipa

Morawska

et al. 2020

IJMS

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One of the major challenges faced by modern nephrology is the identification of biomarkers associated with histopathological patterns or defined pathogenic mechanisms that may assist in the non-invasive diagnosis of kidney disease, particularly glomerulopathy. The identification of such molecules may allow prognostic subgroups to be established based on the type of disease, thereby predicting response to treatment or disease relapse. Advances in understanding the pathogenesis of diseases, such as membranous nephropathy, minimal change disease, focal segmental glomerulosclerosis, IgA (immunoglobulin A) nephropathy, and diabetic nephropathy, along with the progressive development and standardization of plasma and urine proteomics techniques, have facilitated the identification of an increasing number of molecules that may be useful for these purposes. The growing number of studies on the role of TLR (toll-like receptor) receptors in the pathogenesis of kidney disease forces contemporary researchers to reflect on these molecules, which may soon join the group of renal biomarkers and become a helpful tool in the diagnosis of glomerulopathy. In this article, we conducted a thorough review of the literature on the role of TLRs in the pathogenesis of glomerulopathy. The role of TLR receptors as potential marker molecules for the development of neoplastic diseases is emphasized more and more often, as prognostic factors in diseases on several epidemiological backgrounds.

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“…This helps to optimize the diagnostic method and to predict related complications. The biomarkers research regarding diabetes nephropathy, a serious complication of diabetes, has made great progress [10,11], however, study of early diagnosis of T2DM is still limited [12]. To a certain extent, this is due to that the presence of severe metabolic disorders and signs of microvascular damage in the stage of diabetic complications help in the selection of markers; while slight changes in blood glucose and other metabolites in the early stages of diabetes are not likely to be discovered by epidemiological studies.…”

Section: Introductionmentioning

confidence: 99%

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

Wang

et al. 2020

Nutr Metab (Lond)

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Background: Early diagnosis of type 2 diabetes mellitus (T2DM) is still difficult. Screening of plasma biomarkers has great significance of optimizing diagnosis and predicting the complications of T2DM. Methods: We used a special diet, Purina #5008, to induce diabetes in Zucker leptin receptor gene-deficient rats (fa/ fa) to establish Zucker diabetic fatty (ZDF) rats, simulating the early stage of T2DM. The differentially expressed proteins (DEP) and lipids (DEL), as potential biomarkers, were screened to compare the plasma expression levels in ZDF rats and their basic diet-fed wild-type controls (fa/+) by Tandem Mass Tags (TMT) and liquid chromatographytandem mass spectrometry. Results: These two groups had different plasma proteins and lipids profiles consisting of 84 DEPs and, 179 DELs identified in the positive ion mode and 178 DELs in the negative ion mode, respectively. Enrichment analysis of these different indicators showed that oxidative stress, insulin resistance and metabolic disorders of glycan and lipid played an important role in generating the difference. Some markers can be used as candidate biomarkers in prediction and treatments of T2DM, such as ceruloplasmin, apolipoprotein C-I, apolipoprotein C-II and apolipoprotein C-IV. Conclusion: These plasma differences help to optimize the diagnosis and predict the complications of T2DM, although this remains to be verified in the crowd. Trace elements related-metalloproteins, such as ceruloplasmin, and lipid metabolism and transport-related apolipoprotein C are expected to be candidate biomarkers of T2DM and should be given more attention.

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Advances in early biomarkers of diabetic nephropathy

Cited by 60 publications

References 59 publications

Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Toll-Like Receptor as a Potential Biomarker in Renal Diseases

Metalloproteins and apolipoprotein C: candidate plasma biomarkers of T2DM screened by comparative proteomics and lipidomics in ZDF rats

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