Advances in Early Treatment of Combat and Traumatic Shock

Li, Tao; Liu, Liangming

doi:10.1007/978-981-10-2425-2_7

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…Effective on-site emergency measures help to reduce the risk of shock deterioration in trauma patients [22,23]. In the included studies, the measures with high frequency were hemostasis, bandage, ventilation, and establishment of venous access [9-10, 14-15, 18].…”

Section: Prehospital Emergency Carementioning

confidence: 99%

Treatment Strategy of Hemorrhagic Traumatic Shock Patients in High Altitude Area: A Systematic Review

Zhou¹,

Zhou²,

Li³

et al. 2020

Preprint

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Background Because of the influence of hypoxia, the degree of shock of patients with traumatic hemorrhagic shock (HTS) in high altitude area will be aggravated in a short period of time. There is a difference in treatment strategy compared with the low altitude area. At present, the relevant literature reports are growing. However, there is no systematic review of these clinical evidences. Therefore, this study aims to synthesize existing literature on the treatment strategy of HTS patients in high altitude area. Methods By searching PubMed, Medline, Embase, CNKI, CBMdisc, VIP and the Cochrane Database of Systematic Reviews, searched from inception until March 1, 2020. The clinical trial of HTS patients at high altitude, which was conducted by qualitative analysis to extract data, classify, summarize and arrange information. Results Overall, 254 articles were identified, of which 13 relevant articles were identified following screening. Clinical practice and rationale for treatment decisions mainly involve the following 6 aspects: (1) effective prehospital treatment (hemostasis, bandaging, ventilation and establishment of venous access, etc.); (2) long time and low concentration oxygen supply; (3) limited rehydration, the amount of rehydration being 1–2 times of the patient's blood loss; (4) the microcirculation of patients was improved by drug intervention and rewarming; (5) lanatoside C or cedilanid was used to improve the cardiopulmonary function of patients; (6) 5% sodium bicarbonate was used to improve the acid-base balance of patients. In addition, ARDS, MOF and PTPI are the main complications leading to death. Conclusions The level of oxygen supply, rehydration and other treatment strategies for HTS patients in high altitude area are different from those in low altitude areas. The dynamic changes of physiological indexes in the process of treatment are important signs of adjusting the treatment plan. Effective prehospital first aid and rapid medical transport have a positive effect on patients' later rehabilitation.

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Section: Prehospital Emergency Carementioning

confidence: 99%

Treatment Strategy of Hemorrhagic Traumatic Shock Patients in High Altitude Area: A Systematic Review

Zhou¹,

Zhou²,

Li³

et al. 2020

Preprint

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“…Death from hemorrhage represents a substantial global problem, with more than 60,000 deaths per year in the United States and an estimated 1.9 million deaths per year worldwide, 1.5 million of which result from physical trauma [2] , and other clinical medical diseases such as esophageal variceal bleeding, gastric ulcer hemorrhage, obstetric hemorrhage can also lead to hemorrhagic shock. Data show that large blood loss and shock account for nearly 50% of war trauma deaths [3] , especially early death, so the early and efficient treatment of hemorrhagic shock is extremely important.…”

Section: Introductionmentioning

confidence: 99%

Blood+ proteomics reveals hemorrhagic shock mechanisms in a severe hemorrhagic shock rat model

Hao

Zheng

et al. 2023

Preprint

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ABATRACT: Hemorrhagic shock is one of the most important complications of war trauma and an important cause of early death from trauma, so timely diagnosis and treatment are of overwhelming importance. A rat model of 65% severe hemorrhagic shock was established to analyze the different proteins in the plasma between normal rats and predict the mechanism preliminarily by Blood+ proteomics. The results showed that a total of 190 regulated proteins were detected in plasma in rats with severe hemorrhagic shock compared to normal rats. Bioinformatics and enrichment analysis of regulated proteins showed that they were widely distributed in 45 signaling pathways. Of these, 25 of the 190 proteins were enriched in the PI3K-Akt signaling pathway, indicating a strong link between this pathway and severe ischemia. Other enrichment pathways in this study include primary immunodeficiency (PID), toll-like receptor signaling pathway, ECM-receptor interaction, all of which are closely related to autoimmune disorders, inflammatory responses, and anti-inflammatory responses. In conclusion, this study revealed an overview of the framework of protein changes in the plasma of rats with severe hemorrhagic shock, and preliminarily analyzed the mechanism of initial response to severe ischemia.

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Advances in Early Treatment of Combat and Traumatic Shock

Cited by 2 publications

References 55 publications

Treatment Strategy of Hemorrhagic Traumatic Shock Patients in High Altitude Area: A Systematic Review

Treatment Strategy of Hemorrhagic Traumatic Shock Patients in High Altitude Area: A Systematic Review

Blood+ proteomics reveals hemorrhagic shock mechanisms in a severe hemorrhagic shock rat model

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