Advances in eicosanoid research, novel therapeutic implications

Haeggström, Jesper Z.; Rinaldo-Matthis, Agnes; Wheelock, Craig E.; Wetterholm, Anders

doi:10.1016/j.bbrc.2010.03.140

Cited by 96 publications

(75 citation statements)

References 47 publications

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“…COX-2 is an inducible enzyme called upon by tissue injury and other stimuli such as lipopolysaccharide (LPS), interleukin-1, and tumor necrosis factor alpha (TNFα) [15,16]. It is active at injury sites and in a variety of tissues such as the vascular endothelium, and rheumatoid synovial endothelial cells mediating inlammatory, pain, fever, and carcinogenic responses [17,18]. A manifold increase in COX-2 levels occurs in inlammatory processes triggering an increased synthesis of pro-inlammatory prostaglandins.…”

Section: Cox and Cox Inhibitionmentioning

confidence: 99%

Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs

Osafo¹,

Agyare²,

Obiri³

et al. 2017

Nonsteroidal Anti-Inflammatory Drugs

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The use of nonsteroidal anti-inlammatory drugs (NSAIDs) dates back to thousands of years when man used natural sources of these agents in a lot of pain and inlammatory conditions. The tone for modern day discovery and use of NSAIDs was set with the discovery of aspirin. Today in addition to aspirin, a host of other NSAIDs of varying potency and eicacy is employed in the management of pain and inlammatory conditions. This chapter looks with key interest in the existing and evolving role of NSAIDs in therapeutics with emphasis on the current insights into their mechanism of action and side efect proiles associated with its use in pain and inlammation as well as its potential therapeutic beneits in cancer chemotherapy.

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Section: Cox and Cox Inhibitionmentioning

confidence: 99%

Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs

Osafo¹,

Agyare²,

Obiri³

et al. 2017

Nonsteroidal Anti-Inflammatory Drugs

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“…Most researchers consider that the effects of cPLA 2 a in tumor migration and invasion are mainly dependent on the eicosanoids, which have crucial effects in inflammation and cancer [33] . The downstream effects and relevant signaling pathways of the eicosanoids are mainly mediated by G protein-coupled receptors [34] . Napoleon et al [35] showed that AA could promote the migration of breast cancer cells through activation of the focal adhesion kinase (FAK).…”

Section: Cpla 2 a And Diseasesmentioning

confidence: 99%

Cytosolic phospholipase A2 and its role in cancer

Tian

Zhang

2011

Clin. Oncol. Cancer Res.

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Cytosolic phospholipase A 2 a (cPLA 2 a) catalyzes the release of arachidonic acid (AA) and lysophosphoglyceride from membrane phospholipids. Although the roles of AA and eicosanoids in cellular viability, the processes of inflammation and cancer cell development have been extensively studied, the function of cPLA 2 a in the processes of inflammation and cancer cell development is not clear. This review summarizes published evidences for the biochemical properties and regulatory mechanisms of cPLA 2 a. The potential for use of cPLA 2 a as a novel diagnostic target and predictive biomarker for tumors is also discussed.KEY WORDS: cytosolic phospholipase A 2 a, arachidonic acid, chemotaxis.

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“…The most common fatty acids released are AA and it is released together with lysophosphatidic acid (LPA). Released AA can be metabolized by at least three different pathways: the lipoxygenase pathway to form leukotrienes and lipoxins [62], the cyclooxygenase pathway to form prostaglandins [62], or the cytochrome P450 pathway to form cis-or trans-epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids [63]. These three lipid metabolism pathways can use AA to generate more than 25 different bioactive lipids [64].…”

Section: P2x7r and The Lipid Metabolism Signaling Pathwaymentioning

confidence: 99%

Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view

Costa-Junior

Marques-da-Silva

Vieira

et al. 2011

Purinergic Signalling

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For decades, scientists have described numerous protein pathways and functions. Much of a protein's function depends on its interactions with different partners, and those partners can change depending on the cell type or system. The P2X7 receptor (P2X7R) is one such multifunctional protein that is related to multiple partners and signaling pathways. The relationship between P2X7R and different enzymes involved in lipid metabolism represents a relatively new field in P2X7R research. This field of research began in epithelial cells and currently includes immune and nervous cells. The P2X7R-lipid metabolism pathway is related to many biological functions of P2X7R, such as cell death and pathogen clearance, and this signaling pathway may be involved in many functions that are dependent on bioactive lipids. In the present review, we will attempt to summarize data related to the P2X7R-lipid metabolism pathway, focusing on signaling pathways and their biological relevance to the immune system and infection.

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Advances in eicosanoid research, novel therapeutic implications

Cited by 96 publications

References 47 publications

Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs

Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs

Cytosolic phospholipase A2 and its role in cancer

Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view

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