Advances in enantiomeric resolution on monolithic chiral stationary phases in liquid chromatography and electrochromatography

ALOthman, Zeid A.; Al–Warthan, Abdulrahman; Ali, Imran

doi:10.1002/jssc.201301326

Cited by 132 publications

(66 citation statements)

References 169 publications

(247 reference statements)

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“…It is attractive to report that the reported profens have a benzene ring facilitating π–π interactions among the antipodes and chiral amylose derivatives. It is already established that π–π interactions are crucial in the chiral separation of many aromatic racemates . The setting of all the antipodes of profens in the derivatized amylose grooves is depicted in Figures .…”

Section: Resultsmentioning

confidence: 99%

Chiral separation and modeling of baclofen, bupropion, and etodolac profens on amylose reversed phase chiral column

et al. 2017

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Chiral resolution of baclofen, bupropion, and etodolac profens was obtained with amylose derivatized chiral reversed stationary phase (carbamate groups). The eluent used for bupropion and etodolac was MeOH-water (20:80, v/v) and for baclofen was water-methanol (95:5, v/v). The eluent run rates, finding wavelength and temperature, were 1.0 mL/min, 220 nm and 27 ± 1 °C for all the eluents. The magnitude of the retardation factors for S- and R-enantiomers of baclofen, bupropion, and etodolac were 1.37, 2.62, 2.25, 3.25, 1.8, and 3.0. The magnitudes of separation and resolution factors were 1.90, 1.44, and 1.67 and 2.77, 2.35, and 2.04. Limits of detection and quantitation were 1.0-2.0 and 5.1-10.0 μg/mL. Chiral recognition mechanisms were recognized by simulation and high-performance liquid chromatography (HPLC) experiments. It was seen that hydrogen interactions, hydrophobic interactions, and π-π exchanges were the chief interactions for chiral recognition mechanisms. The described methods may be exploited for the chiral separation of baclofen, bupropion, and etodolac profens in any unknown sample.

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Section: Resultsmentioning

confidence: 99%

Chiral separation and modeling of baclofen, bupropion, and etodolac profens on amylose reversed phase chiral column

et al. 2017

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“…The amylose‐based CSPs, in general, demonstrated better enantioseparation capacity than the cellulose‐based one. Probably, it was due to higher helical nature of amylose in comparison to cellulose . A useful observation was made that the modification of the mobile phase by a “nonstandard” solvent, such as chloroform or 2‐ethoxyethanol, may improve enantioseparation to a degree.…”

Section: Chiral Resolution By Hplcmentioning

confidence: 99%

Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

2017

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The quinolones are derivatives of oxoquinolines and mostly known for their antibacterial and antiviral activities. Many quinolones are chiral compounds having asymmetric centers and important due to their enantioselective biological activities. In order to study the biological activities of quinolone enantiomers, to control the manufacturing of homochiral drugs and to prepare necessary quantities of pure enantiomers for preclinical or clinical trials, respective chiral separation methods are urgently needed. In this context, the present review discusses chromatographic and electrophoretic methods for the enantioseparation of chiral quinolones and provides some useful information on their physical and pharmaceutical properties. The drawbacks of currently used techniques are revealed and ways to overcome them are outlined. Moreover, recommendations for an optimal choice of a separation protocol are given.

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“…Assessed 30 25 different stationary phases to resolve a training set of 80 chiral molecules, using SFC (super critical flu0id chromatography). The columns were divided into 8 different classes, based on column chemistries, summarised in Table 2.…”

Section: Chiral Stationary Phasesmentioning

confidence: 99%

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2017

IJPSR

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Impurities will be present in all drug substances and drug products, i.e. nothing is 100% pure if one looks in enough depth. The current regulatory guidance on impurities accepts this, and for drug products with a dose of less than 2 g/day identification of impurities is set at 0.1% levels and above (ICH Q3B (R2), 2006). For some impurities, this is a simple undertaking as generally available analytical techniques can address the prevailing analytical challenges; whereas, for others this may be much more challenging requiring more sophisticated analytical approaches. The present review provides an insight into current development of analytical techniques to investigate and quantify impurities in drug substances and drug products providing discussion of progress particular within the field of chromatography to ensure separation of and quantification of those related impurities. Further, a section is devoted to the identification of classical impurities, but in addition, inorganic (metal residues) and solid state impurities are also discussed. Risk control strategies for pharmaceutical impurities aligned with several of the ICH guidelines, are also discussed.

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Advances in enantiomeric resolution on monolithic chiral stationary phases in liquid chromatography and electrochromatography

Cited by 132 publications

References 169 publications

Chiral separation and modeling of baclofen, bupropion, and etodolac profens on amylose reversed phase chiral column

Chiral separation and modeling of baclofen, bupropion, and etodolac profens on amylose reversed phase chiral column

Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

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