Advances in endophenotyping schizophrenia

Braff, David L.; Greenwood, Tiffany A.; Swerdlow, Neal R.; Light, Gregory A.; Schork, Nicholas J.

doi:10.1002/j.2051-5545.2008.tb00140.x

Cited by 88 publications

(69 citation statements)

References 88 publications

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“…Neurocognitive functioning is another main symptom category in psychotic disorders [15][16][17][18]. Three of the most impaired neurocognitive functions in psychotic disorders are sustained attention, immediate recall and delayed recall [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Cognitive deficits and ethnicity: a cohort study of early psychosis patients in The Netherlands

Stouten

Veling

Helm

et al. 2012

Soc Psychiatry Psychiatr Epidemiol

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Purpose Incidence rates of psychotic disorders are higher in immigrant groups compared to native populations. This increased risk may partly be explained by misdiagnosis. Neurocognitive deficits are a core feature of psychotic disorders, but little is known about the relationship between migration and cognition in psychotic disorders. We examined whether immigrant patients have cognitive deficits similar to non-immigrant patients, in order to investigate the plausibility of misdiagnosis as explanation for increased incidence rates. Methods Patients who made first contact for non-affective psychotic disorder were assessed in the cognitive domains sustained attention, immediate recall and delayed recall. Immigrant patients were compared to Dutch patients on cognitive performance. Results 407 Patients diagnosed with a non-affective psychotic disorder completed cognitive assessment (157 Dutch, 250 immigrants). Both Dutch and immigrant patients showed large cognitive deficits. Between-subgroup comparisons revealed large cognitive deficits for immigrants compared to Dutch, especially for immigrants from Morocco, Turkey and other non-Western countries. Conclusions These results indicate that immigrant status is associated with poorer cognitive functioning in early psychosis. The findings argue against diagnostic bias as an explanation for the increased incidence of psychotic disorders in immigrants.

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Section: Introductionmentioning

confidence: 99%

Cognitive deficits and ethnicity: a cohort study of early psychosis patients in The Netherlands

Stouten

Veling

Helm

et al. 2012

Soc Psychiatry Psychiatr Epidemiol

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“…Finally, as neurocognitive impairment in schizophrenia is a significant predictor of outcome 12 and has been suggested to be a particularly suitable trait for the genetic study of schizophrenia, 13 we searched for genetic predictors of cognitive change, utilizing data from detailed cognitive assessments performed throughout the CATIE trial and reflecting various measures of verbal learning and memory, working memory, motor function, attention and executive function. All phenotypes in this paper were defined before genetic analyses were performed to prevent false positives due to unconstrained or biased data mining.…”

mentioning

confidence: 99%

Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis

Need¹,

Keefe

Ge³

et al. 2009

Eur J Hum Genet

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“…In rodents, PPI is commonly measured as whole-body startle responses, whereas in human experiments, generally eye-blink responses are used. In theory, deficient PPI in schizophrenic patients reflects a dysfunction in the gating of sensory and cognitive information, clinically manifesting as a patient's inability to filter irrelevant thoughts and sensory stimuli from intruding into awareness (Braff et al, 1978;Braff et al, 2008). Some cross-sectional and longitudinal studies demonstrate that in patients, deficits in sensorimotor gating are improved by atypical antipsychotics Aggernaes et al, 2010).…”

Section: Prepulse Inhibition Of the Startle Responsementioning

confidence: 99%