2023
DOI: 10.3389/fcell.2023.1168215
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Advances in epidemiological status and pathogenesis of dental fluorosis

Abstract: Fluoride is commonly consider as a “double-edged sword” because low consumption of fluoride can effectively prevent dental caries, but excessive consumption of fluoride can cause fluorosis. Dental fluorosis (DF) is a characteristic feature of fluorosis in the oral cavity that is manifested as tooth color changes and evident enamel defect. Presently, the pathogenesis of DF remains unclear. Herein, we have summarized the research progress in the pathogenesis and mechanism of DF in the past 5 years.

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Cited by 5 publications
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“…Excess iodine also poses health risks to the body, mainly to the thyroid, causing thyroiditis, hyperthyroidism, hypothyroidism, and goiter (9). Excess fluoride in drinking water harms the body, primarily in the teeth and bones and even the nervous and urinary systems in serious cases (10,11). There is growing concern that children are sensitive to endemic fluorosis, especially regarding the effects of fluoride on their mental development (12).…”
Section: Introductionmentioning
confidence: 99%
“…Excess iodine also poses health risks to the body, mainly to the thyroid, causing thyroiditis, hyperthyroidism, hypothyroidism, and goiter (9). Excess fluoride in drinking water harms the body, primarily in the teeth and bones and even the nervous and urinary systems in serious cases (10,11). There is growing concern that children are sensitive to endemic fluorosis, especially regarding the effects of fluoride on their mental development (12).…”
Section: Introductionmentioning
confidence: 99%