2016
DOI: 10.1039/c6ra06640b
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Advances in exploring alternative Taxol sources

Abstract: The protection and sustainable utilization of natural resources are among the most pressing global problems of the 21st century.

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Cited by 79 publications
(46 citation statements)
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“…Typically, if the xylosyl group of XDT is removed, the corresponding 10-deacetyltaxol (DT) can be converted into Taxol by acetylation at the C10 position. However, such analogue is generally discarded during Taxol extraction, leading to both resource waste and potential environmental pollution 11 . In our previous study, two variants, LXYL-P1−1 and LXYL-P1−2 with dual GH3 β -xylosidase/ β -glucosidase activities, were cloned from Lentinula edodes (strain M95.33) and characterized.…”
Section: Introductionmentioning
confidence: 99%
“…Typically, if the xylosyl group of XDT is removed, the corresponding 10-deacetyltaxol (DT) can be converted into Taxol by acetylation at the C10 position. However, such analogue is generally discarded during Taxol extraction, leading to both resource waste and potential environmental pollution 11 . In our previous study, two variants, LXYL-P1−1 and LXYL-P1−2 with dual GH3 β -xylosidase/ β -glucosidase activities, were cloned from Lentinula edodes (strain M95.33) and characterized.…”
Section: Introductionmentioning
confidence: 99%
“…With the development of its new indications and formulations, its clinical application has also expanded. Both the domestic and overseas market demand for paclitaxel is still increasing, although the natural concentrations in yew plants is extremely low [ 4 , 5 ]. 7-β-Xylosyltaxanes, such as 7-β-xylosyl-10-deacetyltaxol (XDT), are the analogues of paclitaxel produced by yew plants ( Taxus species), which are generally discarded during paclitaxel extraction, leading to both resource waste and potential environmental pollution [ 4 , 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…Larotaxel has a much lower affinity for P-glycoprotein 1 than docetaxel and is shown to be active in cell lines resistant to doxorubicin, vinblastine, paclitaxel and docetaxel [7] . The antitumor activity in non-small cell lung cancer, the reproducible profile of toxicity and the ability to cross the blood-brain barrier make larotaxel worthy of further disease-oriented clinical development [8] , [9] , [10] . Since new molecular entities are evaluated in clinical development, the understanding, identification and control of degradation products or impurities in drug substances are essential, which can also assist the development of proper formulations and storage conditions of the drugs [11] , [12] .…”
Section: Introductionmentioning
confidence: 99%