Advances in exploring the therapeutic potential of marine natural products

Liang, Xiao; Luo, Danmeng; Luesch, Hendrik

doi:10.1016/j.phrs.2019.104373

Cited by 86 publications

(63 citation statements)

References 157 publications

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“…Natural products (NPs) are a rich source of diverse bioactive molecules for discovery of therapeutic drugs. [1][2][3] In addition, NPs serve as valuable probes to study the inner workings of the cell and have revealed a wealth of information about dynamic cellular processes such as mechanisms of protein synthesis, secretion, and regulated turnover. 4 However, to gain relevant insights into biological systems and disease mechanisms, high quality probe molecules are required and many small molecules that are currently used do not fulll the required criteria.…”

Section: Introductionmentioning

confidence: 99%

Natural products as modulators of eukaryotic protein secretion

Luesch

Paavilainen

2020

Nat. Prod. Rep.

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Covering: up to the end of 2019 Diverse natural product small molecules have allowed critical insights into processes that govern eukaryotic cells' ability to secrete cytosolically synthesized secretory proteins into their surroundings or to insert newly synthesized integral membrane proteins into the lipid bilayer of the endoplasmic reticulum. In addition, many components of the endoplasmic reticulum, required for protein homeostasis or other processes such as lipid metabolism or maintenance of calcium homeostasis, are being investigated for their potential in modulating human disease conditions such as cancer, neurodegenerative conditions and diabetes. In this review, we cover recent findings up to the end of 2019 on natural products that influence protein secretion or impact ER protein homeostasis, and serve as powerful chemical tools to understand protein flux through the mammalian secretory pathway and as leads for the discovery of new therapeutics.

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Section: Introductionmentioning

confidence: 99%

Natural products as modulators of eukaryotic protein secretion

Luesch

Paavilainen

2020

Nat. Prod. Rep.

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“…The wide chemical space occupied by the secondary metabolites of living organisms and microorganisms is an authentic example of how combinatorial chemistry has been performed by nature for thousands of years, giving a real arsenal of drug lead candidates [ 4 ]. The marine environment covers 71% of the Earth’s surface and comprises 50–80% of the total global biodiversity, which translates into an enormous chemical diversity [ 5 ]; every year, hundreds of novel compounds are isolated and identified, especially from marine invertebrates [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. In fact, these species are sessile or slow moving and soft bodied; although they commonly host microorganisms, they lack the sophisticated adaptable immune systems seen in vertebrates.…”

Section: Introductionmentioning

confidence: 99%

The Ascidian-Derived Metabolites with Antimicrobial Properties

2020

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Among the sub-phylum of Tunicate, ascidians represent the most abundant class of marine invertebrates, with 3000 species by heterogeneous habitat, that is, from shallow water to deep sea, already reported. The chemistry of these sessile filter-feeding organisms is an attractive reservoir of varied and peculiar bioactive compounds. Most secondary metabolites isolated from ascidians stand out for their potential as putative therapeutic agents in the treatment of several illnesses like microbial infections. In this review, we present and discuss the antibacterial activity shown by the main groups of ascidian-derived products, such as sulfur-containing compounds, meroterpenes, alkaloids, peptides, furanones, and their derivatives. Moreover, the direct evidence of a symbiotic association between marine ascidians and microorganisms shed light on the real producers of many extremely potent marine natural compounds. Hence, we also report the antibacterial potential, joined to antifungal and antiviral activity, of metabolites isolated from ascidian-associate microorganisms by culture-dependent methods.

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“…[ 11–13 ] Bioactive ingredients derived from natural products, primarily TCM, are commonly used around the world because of their high bioavailability and because they are highly safe, have minimal adverse reactions and, most importantly, are cost‐effective. [ 14 ] Also, due to its long history in clinical practice and numerous historical cases, TCM is a helpful resource for identifying anticancer active constituents. [ 15 ] Currently, although there is still a definitive lack of modern biological studies for the treatment of cancer using TCM, the clinical efficacy is apparent.…”

Section: Introductionmentioning

confidence: 99%

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

Luan

Zeng

2020

Journal of Pharmacy and Pharmacology

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Objectives Tetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising anticancer activities on diverse tumours. This review provides systematically organized information on cancers of tetrandrine in vivo and in vitro, discuss the related molecular mechanisms and put forward some new insights for the future investigations. Key findings Anticancer activities of tetrandrine have been reported comprehensively, including lung cancer, colon cancer, bladder cancer, prostate cancer, ovarian cancer, gastric cancer, breast cancer, pancreatic cancer, cervical cancer and liver cancer. The potential molecular mechanisms corresponding to the anticancer activities of tetrandrine might be related to induce cancer cell apoptosis, autophagy and cell cycle arrest, inhibit cell proliferation, migration and invasion, ameliorate metastasis and suppress tumour cell growth. Pharmaceutical applications of tetrandrine combined with nanoparticle delivery system including liposomes, microspheres and nanoparticles with better therapeutic efficiency have been designed and applied encapsulate tetrandrine to enhance its stability and efficacy in cancer treatment. Summary Tetrandrine was proven to have definite antitumour activities. However, the safety, bioavailability and pharmacokinetic parameter studies on tetrandrine are very limited in animal models, especially in clinical settings. Our present review on anticancer potentials of tetrandrine would be necessary and highly beneficial for providing guidelines and directions for further research of tetrandrine.

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Advances in exploring the therapeutic potential of marine natural products

Cited by 86 publications

References 157 publications

Natural products as modulators of eukaryotic protein secretion

Natural products as modulators of eukaryotic protein secretion

The Ascidian-Derived Metabolites with Antimicrobial Properties

Tetrandrine: a review of its anticancer potentials, clinical settings, pharmacokinetics and drug delivery systems

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