Advances in fabricating double-emulsion droplets and their biomedical applications

Chong, Daotong; Liu, XinShi; Ma, HuaJie; Huang, Guangsu; Han, Yu; Cui, Xingye; Yan, Junjie; Xu, Feng

doi:10.1007/s10404-015-1635-8

Cited by 124 publications

(84 citation statements)

References 149 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, traditional microsphere fabrication techniques such as emulsification and emulsion polymerization often require the addition of a surfactant, which may change the biodistribution, biodegradability and drug release behavior of the drug loaded microspheres404142. Thermally induced phase separation (TIPS) has been widely used for fabrication of various scaffolds43.…”

Section: Resultsmentioning

confidence: 99%

Dual Drug Loaded Biodegradable Nanofibrous Microsphere for Improving Anti-Colon Cancer Activity

Fan

Deng

et al. 2016

Sci Rep

View full text Add to dashboard Cite

One of the approaches being explored to increase antitumor activity of chemotherapeutics is to inject drug-loaded microspheres locally to specific anatomic sites, providing for a slow, long term release of a chemotherapeutic while minimizing systemic exposure. However, the used clinically drug carriers available at present have limitations, such as their low stability, renal clearance and residual surfactant. Here, we report docetaxel (DOC) and curcumin (CUR) loaded nanofibrous microspheres (DOC + CUR/nanofibrous microspheres), self-assembled from biodegradable PLA-PEO-PPO-PEO-PLA polymers as an injectable drug carrier without adding surfactant during the emulsification process. The obtained nanofibrous microspheres are composed entirely of nanofibers and have an open hole on the shell without the assistance of a template. It was shown that these DOC + CUR/nanofibrous microspheres could release curcumin and docetaxel slowly in vitro. The slow, sustained release of curcumin and docetaxel in vivo may help maintain local concentrations of active drug. The mechanism by which DOC + CUR/nanofibrous microspheres inhibit colorectal peritoneal carcinomatosis might involve increased induction of apoptosis in tumor cells and inhibition of tumor angiogenesis. In vitro and in vivo evaluations demonstrated efficacious synergistic antitumor effects against CT26 of curcumin and docetaxel combined nanofibrous microspheres. In conclusion, the dual drug loaded nanofibrous microspheres were considered potentially useful for treating abdominal metastases of colorectal cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Dual Drug Loaded Biodegradable Nanofibrous Microsphere for Improving Anti-Colon Cancer Activity

Fan

Deng

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Extensive studies have been conducted on droplet microfluidic device fabrication, device geometries, and breakup mechanisms . Conventional methods of producing droplets such as emulsion polymerization, suspension polymerization, or evaporation‐induced consolidation, usually do not guarantee high monodispersity . Microfluidic approach allows precise control over size, shape, and morphologies of microdroplets.…”

Section: Microfluidics For Environmental Remediationmentioning

confidence: 99%

A Review of State‐of‐the‐Art Microfluidic Technologies for Environmental Applications: Detection and Remediation

et al. 2018

View full text Add to dashboard Cite

Microfluidic systems have advanced beyond natural and life science applications and lab‐on‐a‐chip uses. A growing trend of employing microfluidic technologies for environmental detection has emerged thanks to the precision, time‐effectiveness, and cost‐effectiveness of advanced microfluidic systems. This paper reviews state‐of‐the‐art microfluidic technologies for environmental applications, such as on‐site environmental monitoring and detection. Microdevices are extensively used in collecting environmental samples as a means to facilitate detection and quantification of targeted components with minimal quantities of samples. Likewise, microfluidic‐inspired approaches for separation and treatment of contaminated water and air, such as the removal of heavy metals and waterborne pathogens from wastewater and carbon capture are also investigated.

show abstract

“…Passive processes provide a smaller degree of control over the droplet formation, because the operations are hard-wired into the geometries of the devices. Droplet formation also depends on the parameters of used fluids, however, to a smaller extent than on the geometry (Chong et al, 2015;Van Der Graaf et al, 2005). A first system for passive encapsulation of the precisely controlled number of cores inside a double-emulsion droplet has been shown just recentlythe single emulsion is used as the feed.…”

Section: Production Of Multiple Emulsionsmentioning

confidence: 99%

“…4 depicts selected and the most common methods for the generation of DE in microfluidic channels. For more information on double emulsion generation, the reader is encouraged to study excellent reviews on the subject (Chong et al, 2015;Vladisavljević et al, 2017;Zhu and Wang, 2017).…”

Section: Production Of Multiple Emulsionsmentioning

confidence: 99%

Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions

Opalski

Kamiński

Garstecki

2019

KONA

View full text Add to dashboard Cite

Emulsion-a liquid dispersed in another liquid-is in many respects very similar to granular matter. In the early 2000s a new technology-droplet microfluidics-began emerging from the wider field of microfluidics. Droplet microfluidics was quickly established as a discipline of science and engineering and has been used for the generation of highly uniform emulsions. The last few years have brought significant advances to the field, directed towards a wide range of applications in material sciences-from synthesis of nanoparticles in droplets to assembling complex droplets and using droplets as templates for ordered materials, with applications in food, cosmetic and diagnostic industries. Droplet microfluidic platforms are also successfully used as analytical tools in molecular biology and biochemistry, in e.g. high-throughput screening, digital assays, encapsulation of single cells, sequencing technologies, and in point-of-care diagnostic applications. This article provides an accessible overview of the physical phenomena observed in multiphase flow at the microscale and the techniques in droplet microfluidics systems. We also present the most interesting applications and potential further directions of research in this fascinating young field of science and engineering.

show abstract

Advances in fabricating double-emulsion droplets and their biomedical applications

Cited by 124 publications

References 149 publications

Dual Drug Loaded Biodegradable Nanofibrous Microsphere for Improving Anti-Colon Cancer Activity

Dual Drug Loaded Biodegradable Nanofibrous Microsphere for Improving Anti-Colon Cancer Activity

A Review of State‐of‐the‐Art Microfluidic Technologies for Environmental Applications: Detection and Remediation

Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions

Contact Info

Product

Resources

About