Advances in Factors Affecting ALDH2 Activity and its Mechanisms

Liu, Yun; Liu, Xuemei; Pan, Chang

doi:10.1007/s12012-024-09923-9

Cardiovasc Toxicol

2024

DOI: 10.1007/s12012-024-09923-9

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Advances in Factors Affecting ALDH2 Activity and its Mechanisms

Yun Liu,

Xuemei Liu,

Chang Pan

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2024

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The Significance of Aldehyde Dehydrogenase 1 in Cancers

Nguyen,

Facey,

Boman

2024

IJMS

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The goal of this paper is to discuss the role of ALDH isozymes in different cancers, review advances in ALDH1-targeting cancer therapies, and explore a mechanism that explains how ALDH expression becomes elevated during cancer development. ALDH is often overexpressed in cancer, and each isoform has a unique expression pattern and a distinct role in different cancers. The abnormal expression of ALDHs in different cancer types (breast, colorectal, lung, gastric, cervical, melanoma, prostate, and renal) is presented and correlated with patient prognosis. ALDH plays a significant role in various cellular functions, such as metabolism, oxidative stress response, detoxification, and cellular differentiation. Among the ALDH families, ALDH1 has gained considerable attention as a cancer stem cell (CSC) marker due to its significant role in the maintenance of stemness and the differentiation of stem cells (SCs), along with its involvement in tumorigenesis. A description of the cellular mechanisms and physiology of ALDH1 that underlies cancer development is provided. Moreover, current advances in ALDH1-targeting cancer therapies are discussed.

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The Significance of Aldehyde Dehydrogenase 1 in Cancers

Nguyen,

Facey,

Boman

2024

IJMS

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show abstract

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Advances in Factors Affecting ALDH2 Activity and its Mechanisms

Cited by 1 publication

References 92 publications

The Significance of Aldehyde Dehydrogenase 1 in Cancers

The Significance of Aldehyde Dehydrogenase 1 in Cancers

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