Advances in fecal microbiota transplantation for the treatment of diabetes mellitus

Zhang, Juan; Wang, Honggang; Liu, Ying; Shi, Min; Zhang, Minna; Zhang, Hong; Chen, Juan

doi:10.3389/fcimb.2024.1370999

Cited by 4 publications

References 156 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Gut microbiota predict retinopathy in patients with diabetes: A longitudinal cohort study

Qin,

Sun,

Chen

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

The gut microbiota has emerged as an independent risk factor for diabetes and its complications. This research aimed to delve into the intricate relationship between the gut microbiome and diabetic retinopathy (DR) through a dual approach of cross-sectional and prospective cohort studies. In our cross-sectional study cross-sectional investigation involving ninety-nine individuals with diabetes, distinct microbial signatures associated with DR were identified. Specifically, gut microbiome profiling revealed decreased levels of Butyricicoccus and Ruminococcus torques group, alongside upregulated methanogenesis pathways among DR patients. These individuals concurrently exhibited lower concentrations of short-chain fatty acids in their plasma. Leveraging machine learning models, including random forest classifiers, we constructed a panel of microbial genera and genes that robustly differentiated DR cases. Importantly, these genera also demonstrated significant correlations with dietary patterns and the molecular profiles of peripheral blood mononuclear cells. Building upon these findings, our prospective cohort study followed 62 diabetes patients over a 2-year period to assess the predictive value of these microbial markers. The results underlined the panel’s efficacy in predicting DR incidence. By stratifying patients based on the predictive genera and metabolites identified in the cross-sectional phase, we established significant associations between reduced levels of Butyricicoccus , plasma acetate, and increased susceptibility to DR. This investigation not only deepens our understanding of how gut microbiota influences DR but also underscores the potential of microbial markers as early indicators of disease risk. These insights hold promise for developing targeted interventions aimed at mitigating the impact of diabetic complications. Key points • Microbial signatures are differed in diabetic patients with and without retinopathy • DR-related taxa are linked to dietary habits and transcriptomic profiles • Lower abundances of Butyricicoccus and acetate were prospectively associated with DR Supplementary Information The online version contains supplementary material available at 10.1007/s00253-024-13316-x.

show abstract

Gut microbiota predict retinopathy in patients with diabetes: A longitudinal cohort study

Qin,

Sun,

Chen

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

Profiling the Gut Microbiome: Practice and Potential

Karabekmez,

Sak

2024

Reference Module in Life Sciences

View full text Add to dashboard Cite

Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus

Luppi,

Aldegheri,

Azzalini

et al. 2024

IJMS

View full text Add to dashboard Cite

Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease that results in the destruction of pancreatic β cells, leading to hyperglycaemia and the need for lifelong insulin therapy. Although genetic predisposition and environmental factors are considered key contributors to T1DM, the exact causes of the disease remain partially unclear. Recent evidence has focused on the relationship between the gut, the oral cavity, immune regulation, and systemic inflammation. In individuals with T1DM, changes in the gut and oral microbial composition are commonly observed, indicating that dysbiosis may contribute to immune dysregulation. Gut dysbiosis can influence the immune system through increased intestinal permeability, altered production of short chain fatty acids (SCFAs), and interactions with the mucosal immune system, potentially triggering the autoimmune response. Similarly, oral dysbiosis may contribute to the development of systemic inflammation and thus influence the progression of T1DM. A comprehensive understanding of these relationships is essential for the identification of biomarkers for early diagnosis and monitoring, as well as for the development of therapies aimed at restoring microbial balance. This review presents a synthesis of current research on the connection between T1DM and microbiome dysbiosis, with a focus on the gut and oral microbiomes in pediatric populations. It explores potential mechanisms by which microbial dysbiosis contributes to the pathogenesis of T1DM and examines the potential of microbiome-based therapies, including probiotics, prebiotics, synbiotics, and faecal microbiota transplantation (FMT). This complex relationship highlights the need for longitudinal studies to monitor microbiome changes over time, investigate causal relationships between specific microbial species and T1DM, and develop personalised medicine approaches.

show abstract

Advances in fecal microbiota transplantation for the treatment of diabetes mellitus

Cited by 4 publications

References 156 publications

Gut microbiota predict retinopathy in patients with diabetes: A longitudinal cohort study

Gut microbiota predict retinopathy in patients with diabetes: A longitudinal cohort study

Profiling the Gut Microbiome: Practice and Potential

Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus

Contact Info

Product

Resources

About