Advances in food allergy in 2017

Keet, Corinne A.; Allen, Katrina J.

doi:10.1016/j.jaci.2018.10.020

Cited by 10 publications

(4 citation statements)

References 76 publications

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“…The review highlights the published standardized treatment for food hypersensitivity. Finally, concluding that there was an increased attention to non -IgE-mediated food sensitivities 142 .…”

Section: Othersmentioning

confidence: 99%

A Review of Naturally Occuring Food Allergens and Their Impact on Health

Chittoor

Saraswath

2022

Biosci., Biotech. Res. Asia

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Allergic reactions to foods influence a remarkable amount of population and are related with significant wellbeing results. It is one of the most significant issues that have expanding consideration. Current comprehension of the turn of events and utilization of allergenic capability of certain types of food proteins is restricted. In spite of the fact that there is a selection of in vivo models for assessing hypersensitivity, none of the current models has been approved, is prescient, or generally acknowledged with respect to their allergen explicit inhibitors. Hence, there is a proceeded with enthusiasm on the knowledge recovery based on food allergy so as to give more enlightening way to the current research field. In this paper, the current status of purification, characterization, and types of food allergens and their impacts is thoroughly reviewed. The present available methods for the allergen assessment (in view of animal, cell and clinical methodologies) are emphasized.

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Section: Othersmentioning

confidence: 99%

A Review of Naturally Occuring Food Allergens and Their Impact on Health

Chittoor

Saraswath

2022

Biosci., Biotech. Res. Asia

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“…Once sensitized, these cells can degranulate and induce food allergic symptoms ( 10 ). Why certain humans respond in this manner is not fully understood; yet, it is likely due to a number of factors including low levels of vitamin D ( 11 ), reduced microbial exposure ( 12 ), alterations in the microbiome ( 13 ), skin Ag exposure ( 14 ), and exposure to advanced glycation end-products ( 15 ). In addition, not all FAs use the same mechanism; there are three classes of allergic disorders—(i) classic, IgE-FA dependent, (ii) mixed IgE/non-IgE, and (iii) non-IgE-dependent disorders like EoE.…”

Section: Introductionmentioning

confidence: 99%

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis

Cortes

Brodsky

Chen³

et al. 2022

Front. Allergy

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Eosinophilic esophagitis (EoE) is a chronic allergy-mediated condition with an increasing incidence in both children and adults. Despite EoE's strong impact on human health and welfare, there is a large unmet need for treatments with only one recently FDA-approved medication for EoE. The goal of this study was to establish swine as a relevant large animal model for translational biomedical research in EoE with the potential to facilitate development of therapeutics. We recently showed that after intraperitoneal sensitization and oral challenge with the food allergen hen egg white protein (HEWP), swine develop esophageal eosinophilia—a hallmark of human EoE. Herein, we used a similar sensitization and challenge treatment and evaluated immunological and pathological markers associated with human EoE. Our data demonstrate that the incorporated sensitization and challenge treatment induces (i) a systemic T-helper 2 and IgE response, (ii) a local expression of eotaxin-1 and other allergy-related immune markers, (iii) esophageal eosinophilia (>15 eosinophils/0.24 mm2), and (iv) esophageal endoscopic findings including linear furrows and white exudates. Thereby, we demonstrate that our sensitization and oral challenge protocol not only induces the underlying immune markers but also the micro- and macro-pathological hallmarks of human EoE. This swine model for EoE represents a novel relevant large animal model that can drive translational biomedical research to develop urgently needed treatment strategies for EoE.

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“…An allergic individual relies on an elimination diet, which is effective only if the food manufacturer informs consumers about the allergen [2,3]. There is growing public interest concerning food allergen labeling due to the increased prevalence of allergies among the worldwide population [1,4,5]. The importance of food allergy as a public health problem has led to its recognition on a global scale of food safety.…”

Section: Introductionmentioning

confidence: 99%

Use of IHF-QD Microscopic Analysis for the Detection of Food Allergenic Components: Peanuts and Wheat Protein

Kalčáková

Tremlová

Pospiech

et al. 2020

Foods

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The aim of the study was to analytically evaluate quantum dots in immunohistofluorescence (IHF-QD) microscopic imaging as detectors of food allergens—peanut and wheat. The experiment was designed as two in silico experiments or simulations: (a) models of pastry samples were prepared with the addition of allergenic components (peanut and wheat protein components) and without the addition of allergenic components, and (b) positive and negative commercial samples underwent food allergen detection. The samples from both simulations were tested by the ELISA and IHF-QD microscopic methods. The primary antibodies (secondary antibodies to a rabbit Fc fragment with labeled CdSe/ZnS QD) were labelled at 525, 585, and 655 nm emissions. The use of quantum dots (QDs) has expanded to many science areas and they are also finding use in food allergen detection, as shown in the study. The study indicated that differences between the ELISA and IHF-QD microscopic methods were not observable among experimentally produced pastry samples with and without allergenic components, although differences were observed among commercial samples. The important value of the study is certainly the differences found in the application of different QD conjugates (525, 585, and 655). The highest contrast was found in the application of 585 QD conjugates that can serve for the possible quantification of present food allergens—peanuts and wheat. The study clearly emphasized that QD can be used for the qualitative detection of food allergens and can represent a reliable analytical method for food allergen detection in different food matrixes.

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Advances in food allergy in 2017

Cited by 10 publications

References 76 publications

A Review of Naturally Occuring Food Allergens and Their Impact on Health

A Review of Naturally Occuring Food Allergens and Their Impact on Health

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis

Use of IHF-QD Microscopic Analysis for the Detection of Food Allergenic Components: Peanuts and Wheat Protein

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