2023
DOI: 10.1186/s40478-023-01682-y
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Advances in genetic abnormalities, epigenetic reprogramming, and immune landscape of intracranial germ cell tumors

Yi Zhang,
Chengyi Zhong,
Xindi Ke
et al.

Abstract: Intracranial germ cell tumors (IGCTs) are a rare subtype of central nervous system neoplasms that predominantly affect young individuals and exhibit a higher incidence in East Asia. IGCTs can be pathologically divided into two main categories: germinomas and non-germinomatous germ cell tumors (NGGCTs). Despite the scarcity of this disease, recent advancements in molecular biology techniques have facilitated the discovery of the inherent genetic and molecular characteristics of IGCTs. Somatic mutations that res… Show more

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