Advances in Genetic Engineering of Ajuga Species

Kayani, Waqas Khan; Hasan, Humna; Mirza, Bushra

doi:10.1007/978-981-13-0535-1_27

Cited by 3 publications

(2 citation statements)

References 121 publications

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“…Ref. [ 127 ] for the very first time reported the biotechnologically enhanced production of phytoecdysteroids in A. bracteosa both via transformation and elicitation. pRi TR-DNA genes were reported to act as key players in the determination of the morphology of hairy roots.…”

Section: Case Studiesmentioning

confidence: 99%

Root Cultures, a Boon for the Production of Valuable Compounds: A Comparative Review

Hussain

Abbas

Nazli

et al. 2022

Plants

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Medicinal plants are an inevitable source of pharmaceutical drugs and most of the world population depends on these plants for health benefits. The increasing global demand for bioactive compounds from medicinal plants has posed a great threat to their existence due to overexploitation. Adventitious root and hairy root culture systems are an alternative approach to the conventional method for mass production of valuable compounds from medicinal plants owing to their rapid growth, biosynthetic and genetic stability. The main purpose of this review is to investigate the recent scientific research published worldwide on the application of adventitious and hairy root cultures to produce valuable compounds from medicinal plants. Furthermore, a comparison of adventitious root vs. hairy root cultures to produce valuable compounds has also been discussed. Various aspects such as medium composition, carbon source, pH, amount of macronutrients, optimization strategy, scale-up cultures, and use of biotic abiotic and nano-elicitors at various concentrations are the topic of discussion in this review. Several studies on adventitious and hairy root cultures of Polygonum multiflorum¸ Withania somnifera¸ Echinacea purpurea and Ajuga bracteosa have been discussed in detail which highlights the importance of elicitation strategies and bioreactor system, presenting commercial applications.

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Section: Case Studiesmentioning

confidence: 99%

Root Cultures, a Boon for the Production of Valuable Compounds: A Comparative Review

Hussain

Abbas

Nazli

et al. 2022

Plants

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“…These compounds often exhibit antioxidant activities and have been studied for their medicinal and pharmacological potential [5]. Many species of the Ajuga genus have ethnobotanical importance and are traditionally used to treat various ailments such as joint pain, sore throat, jaundice, fever, gout, asthma, gastrointestinal disorders, hemorrhoids, and diabetes [6]. Several studies have shown that Ajuga genus consists of 50 species with about 300 taxa, which are mostly distributed in the north temperate zone of the world [7].…”

Section: Introductionmentioning

confidence: 99%

Morphological and biochemical variation of Ajuga chamaecistus Ging. ex Benth. in different habitats of Markazi province in the center of Iran

Mahmoodi,

Bikdeloo,

Khadivi

et al. 2024

BMC Plant Biol

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Background Medicinal plants, such as Ajuga chamaecistus Ging. ex Benth. are a natural and available source of treatment for a wide range of diseases. The objective of the present study was to assess the morphological and biochemical variation of 70 accessions of this species collected from seven geographical areas of Markazi province in the center of Iran. Results The measured traits exhibited considerable variability across the populations. Positive correlations were observed between antioxidant activity and total phenolic content, as well as total flavonoid content. Principal component analysis showed six components explaining 72.15% of the total variance, and the PC1 explained 20.68% of the total variance. The Ward dendrogram based on morphological variables identified two main clusters. Morphological analysis of A. chamaecistus showed a high variation between qualitative and quantitative traits that help the breeders for selecting the desired genotypes. The accessions collected from the Robat-Mil area showed the highest values for the recorded morphological characteristics. Also, the populations of Robat-Mil, Hassanabad, and Khaneh-Miran were characterized by high values of total phenolic content, total flavonoid content, and antioxidant activity, which can be used in various industries, including pharmaceuticals, cosmetics, and food. Conclusions Overall, the present results showed that the best place for the growth of A. chamaecistus with the production of significant contents of phenol and flavonoid is in Robat-Mil area.

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A Review of Punarnava’s Pharmacological Profile Focusing on its Beneficial and Adverse Effects

Tiwari

Soni

Wal

et al. 2023

CTM

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Background: Punarnava is recognized as an essential remedy because it treats a wide range of health problems. It is commonly known as a rejuvenator. Its chemical constituents are all responsible for pharmacological activity in the body in some ways. There is a lot of evidence that the leaves, stems, and roots can be used as medicine. Objective: The morphological, chemical, and pharmacological characteristics of Boerhaavia diffusa are discussed in this article. The purpose of this review is to discuss the pharmacological profile of Punarnava and its chemical elements, as well as the benefits and drawbacks of its steroidal component β-Ecdysone. Method: This article compiled information by reviewing a variety of published articles and research papers from several sources, including Research Gate, WJPRT, IJPSM, Elsevier, Taylor & Francis, Springer Nature, and The Journal of Ayurveda and Integrated Medicine. Result: It is a widely used remedy for numerous ailments among diverse cultural groups, Ayurvedic, and traditional practitioners. To some extent, it is used in a variety of formulations to treat sciatica, cancer, immunomodulation, obesity, diabetes, jaundice, inflammation, asthma, rheumatism, nephrological difficulties, ascites, anemia, and gynaecological disorders. Conclusion: Herbal medications are becoming increasingly popular nowadays. Punarnava is one of the most beneficial herbs available. More analysis is needed to investigate the impacts of each chemical ingredient in Punarnava. β-Ecdysone is a key component of Punarnava, which is both beneficial and detrimental to humans in different ways. Hence, further research is also needed to emphasize the impacts of each Punarnava chemical ingredient.

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Advances in Genetic Engineering of Ajuga Species

Cited by 3 publications

References 121 publications

Root Cultures, a Boon for the Production of Valuable Compounds: A Comparative Review

Root Cultures, a Boon for the Production of Valuable Compounds: A Comparative Review

Morphological and biochemical variation of Ajuga chamaecistus Ging. ex Benth. in different habitats of Markazi province in the center of Iran

A Review of Punarnava’s Pharmacological Profile Focusing on its Beneficial and Adverse Effects

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