Advances in HCV Treatment-Effect of HCV Infection/HCV Treatment (Peg-Ifn/Ribavirin) on Fertility (Ovarian Reserve)

Abstract

Hepatists C Virus is a RNA virus belonging to the Fl aviriridae family. It has been seen in previous studies that HCV infection perse is associated with reduced ovarian reserve and higher cycle cancellation rate in ovarian cycles. Simultaneously treatment of HCV with Pegylated Interferon (PEG-IFN) and ribavirin (RBV) is known to affect the ovarian reserve. Although there are some controversial reports regarding effect of HCV on fertility. Some guidelines have been laid regarding on co-fertility situations where prior to starting treatment cryopreservation of oocytes/embryos should be done by doing an IVF cycle. We discuss such controversial issues in a case who had chronic HCV infection affecting liver function besides bad obstetric disease and needed antiviral therapy for Chronic HCV infection affecting liver function, but whether at her age was doing cryopreservation indicated or justified in view of her age and known effects of HCV treatment on future fertility and risk of spread. We also review the modern advancements in the treatment of HCV infection and their future effects on fertility.