Advances in imaging of uveitis

Marchese, Alessandro; Agarwal, Aniruddha; Moretti, Alessio Grazioli; Handa, Sabia; Modorati, Giulio; Querques, Giuseppe; Bandello, Francesco; Gupta, Vishali; Miserocchi, Elisabetta

doi:10.1177/2515841420917781

Cited by 27 publications

(29 citation statements)

References 152 publications

(97 reference statements)

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“…In human eye disease, improvements in imaging have driven diagnostic sensitivity and specificity (42,43). Scoring systems serve as tools for categorizing disease activity into ordinal groups and as a convenient measure of clinical outcome and directional change.…”

Section: Clinical Scoringmentioning

confidence: 99%

“…Complementary to dye-based angiography are OCT based methodologies. Vascular dilation and perivascular exudate attributed to retinal vasculitis can be localized to specific retinal layers during the course of EAU (23,59) and OCT has been used for imaging vasculature disturbances, such as choroiditis and retinal vasculitis (43). Blood flow can be visualized and depth resolved (94) using OCT angiography (OCTA) and this has been used to assess retinal microvascular changes (95,96).…”

Section: Vasculaturementioning

confidence: 99%

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Quantitative Assessment of Experimental Ocular Inflammatory Disease

et al. 2021

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Ocular inflammation imposes a high medical burden on patients and substantial costs on the health-care systems that mange these often chronic and debilitating diseases. Many clinical phenotypes are recognized and classifying the severity of inflammation in an eye with uveitis is an ongoing challenge. With the widespread application of optical coherence tomography in the clinic has come the impetus for more robust methods to compare disease between different patients and different treatment centers. Models can recapitulate many of the features seen in the clinic, but until recently the quality of imaging available has lagged that applied in humans. In the model experimental autoimmune uveitis (EAU), we highlight three linked clinical states that produce retinal vulnerability to inflammation, all different from healthy tissue, but distinct from each other. Deploying longitudinal, multimodal imaging approaches can be coupled to analysis in the tissue of changes in architecture, cell content and function. This can enrich our understanding of pathology, increase the sensitivity with which the impacts of therapeutic interventions are assessed and address questions of tissue regeneration and repair. Modern image processing, including the application of artificial intelligence, in the context of such models of disease can lay a foundation for new approaches to monitoring tissue health.

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Section: Clinical Scoringmentioning

confidence: 99%

Section: Vasculaturementioning

confidence: 99%

Quantitative Assessment of Experimental Ocular Inflammatory Disease

et al. 2021

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“…Using these devices, it is also possible to obtain montage of FAF images. [22][23][24][25] In addition, ultra-wide field imaging may be superior to conventional imaging in identifying changes such as peripheral paradoxical worsening (worsening of the primary disease upon initiation of anti-TB therapy due to possible release of antigens from the mycobacteria; Ocular Jarisch-Herxheimer reaction) which may be otherwise missed on conventional imaging. Aggarwal et al examined 44 eyes with TB SLC using UWF imaging in detection of paradoxical worsening.…”

Section: Ultrawide-field and Montage Photographymentioning

confidence: 99%

“…EDI-OCT and swept-source OCT help in detection of deeper choroidal involvement in various vitreoretinal conditions including TB SLC. 22,44 Using these tools, choroidal infiltration, elevation of the RPE-Bruch's membrane complex, and focal increase in choroidal thickness have been observed along lesions of TB SLC. During the active stage of the disease, imaging of the choriocapillaris is vital in TB SLC, as it probably reflects the site of the primary pathology.…”

Section: Pathological Changes In the Choroidmentioning

confidence: 99%

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Imaging in Tubercular Choroiditis: Current Concepts

Agarwal

Invernizzi

Markan

et al. 2020

Ocular Immunology and Inflammation

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Purpose: Ocular tuberculosis has protean clinical manifestations. Because of its varied clinical presentation, multimodal imaging is essential to characterize the disease activity, presence of inflammation, determining therapeutic response, and detection of complications. Methods: Narrative reviewResults: In this review, various imaging modalities employed in the management of ocular tuberculosis including fluorescein angiography (FA), indocyanine green angiography (ICGA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) have been reviewed. Not only do these imaging tools complement each other in providing a comprehensive assessment of the pathology, they also help in gaining valuable insights regarding the evolution of the disease.Conclusions: Fundus imaging plays a vital role in the diagnosis and management of patients with posterior uveitis due to tuberculosis. Fundus imaging may have a useful role in defining clinical endpoints for ocular tuberculosis in the future.

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