Advances in ion-doping of Ca-Mg silicate bioceramics for bone tissue engineering

Articular cartilage repair biomaterials: strategies and applications

“…The bioceramics surfaces exhibit biological activity, which can facilitate cell adhesion and growth, and accelerate the repair and regeneration of bone tissue [ 121 ]. Furthermore, bioceramics can be fabricated to possess pore structures and morphologies resembling natural bone tissues, which favor bone cell colonization and growth of bone cells [ 122 ]. The anisotropic tissue lineage and physiological properties of osteochondral tissue remain challenges for cartilage regeneration.…”

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

“…Building on the remarkable performance of composite BGs and ceramics, the integration of diverse bioactive ions, such as copper (Cu), 575,576 zinc (Zn), 577 magnesium (Mg), 578 manganese (Mn), 579 and rare-earth ions, 580,581 in silicon-containing biomaterials has emerged as a promising approach for advanced tissue engineering applications. 582–584 This ion-doping strategy presents several advantages, including simplicity, cost-effectiveness, efficacy at low concentrations, and stability during scaffold processing.…”

Transforming Natural Eggshell and Diatomite into Bioactive Calcium Silicate Material for Bone Regeneration

“…Bone defects have various clinical causes including infection, trauma, and cancer . Over 2.2 million bone graft procedures are performed every year globally to repair bone defects during neurological, oral and maxillofacial, and orthopedic surgeries . While autologous bone grafts are the gold standard for bone repair, their use is limited due to the scarcity of suitable sources and high rate of complications in the bone extraction area, such as infection, pain, and hematoma. , Although allogeneic bone grafts of animal origin are abundant, they are prone to immune rejection and carry a potential risk of disease transmission .…”