Advances in laboratory detection of acute kidney injury

Husain‐Syed, Faeq; Reis, Thiago; Kashani, Kianoush; Ronco, Claudio

doi:10.1016/j.plabm.2022.e00283

Cited by 11 publications

(13 citation statements)

References 128 publications

(167 reference statements)

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“…A prospective study of 549 individuals with biopsy-confirmed kidney disease involved the analysis of 225 circulating plasma proteins and found that KIM-1 was the top-performing marker positively associated with acute tubular injury [ 30 ]. It is significantly activated in response to ischemic and toxic damage to the kidney [ 29 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Potential Biomarkers for the Earlier Diagnosis of Kidney and Liver Damage in Acute Intermittent Porphyria

Storjord,

Wahlin,

Karlsen

et al. 2023

Life

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Acute intermittent porphyria (AIP) is an inherited metabolic disorder associated with complications including kidney failure and hepatocellular carcinoma, probably caused by elevations in the porphyrin precursors porphobilinogen (PBG) and delta-aminolevulinic acid (ALA). This study explored differences in modern biomarkers for renal and hepatic damage between AIP patients and controls. Urine PBG testing, kidney injury panels, and liver injury panels, including both routine and modern biomarkers, were performed on plasma and urine samples from AIP cases and matched controls (50 and 48 matched pairs, respectively). Regarding the participants’ plasma, the AIP cases had elevated kidney injury marker-1 (KIM-1, p = 0.0002), fatty acid-binding protein-1 (FABP-1, p = 0.04), and α-glutathione S-transferase (α-GST, p = 0.001) compared to the matched controls. The AIP cases with high PBG had increased FABP-1 levels in their plasma and urine compared to those with low PBG. In the AIP cases, KIM-1 correlated positively with PBG, CXCL10, CCL2, and TCC, and the liver marker α-GST correlated positively with IL-13, CCL2, and CCL4 (all p < 0.05). In conclusion, KIM-1, FABP-1, and α-GST could represent potential early indicators of renal and hepatic damage in AIP, demonstrating associations with porphyrin precursors and inflammatory markers.

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Section: Discussionmentioning

confidence: 99%

“…Proximal Tubular Damage, 38.7 kDa (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44), transmembrane glycoprotein type-1, also activated in also response to ischemic and toxic kidney damage [29,[31][32][33]. Expressed in: proximal tubular cells, microglial cells, excitatory neurons, oligodendrocytes, and inhibitory neurons [31,32].…”

Section: Analytementioning

confidence: 99%

Potential Biomarkers for the Earlier Diagnosis of Kidney and Liver Damage in Acute Intermittent Porphyria

Storjord,

Wahlin,

Karlsen

et al. 2023

Life

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“…Moreover, certain markers such as asymmetric dimethylarginine, inflammatory/fibrosis parameters (e.g., monocyte chemoattractant protein, transforming growth factor-b1), and Klotho-FGF23 axis raise the most interest as the best selective markers of CKD. A detailed description of the diagnostic application of these markers is beyond the scope of this paper and can be found in numerous reviews dealing specifically with this issue [ 87 , 88 , 89 , 90 , 91 ]. Due to simple laboratory assessment of kidney function, based on blood urea nitrogen (BUN) and creatinine measurement, being an imperfect marker of kidney function, as they are influenced by many renal and non-renal factors, some of the above-mentioned proteins have been proposed as more selective laboratory parameters of kidney dysfunction.…”

Section: Preventive Factors Of Drug-induced Nephrotoxicitymentioning

confidence: 99%

A Synopsis of Current Theories on Drug-Induced Nephrotoxicity

Dobrek

2023

Life

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The overriding goal of the treatment of patients is its effectiveness and safety. However, all medications currently being used also exert some adverse pharmaceutical reactions, which may be regarded as an unintended but inevitable cost of pharmacotherapy. The kidney, as the main organ that eliminates xenobiotics, is an organ especially predisposed and vulnerable to the toxic effects of drugs and their metabolites during their excretion from the body. Moreover, some drugs (e.g., aminoglycosides, cyclosporin A, cisplatin, amphotericin B, and others) have a “preferential” nephrotoxicity potential, and their use is associated with an increased risk of kidney damage. Drug nephrotoxicity is, therefore, both a significant problem and a complication of pharmacotherapy. It should be noted that, currently, there is no generally recognized definition of drug-induced nephrotoxicity and no clear criteria for its diagnosis. This review briefly describes the epidemiology and diagnosis of drug-induced nephrotoxicity and characterizes its pathomechanisms, including immunological and inflammatory disturbances, altered kidney blood flow, tubulointerstitial injury, increased lithogenesis–crystal nephropathy, rhabdomyolysis, and thrombotic microangiopathy. The study also lists the basic drugs with nephrotoxicity potential and provides a short overview of the preventive methods for reducing the risk of drug-related kidney damage developing.

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“…Currently used AKI biomarkers, urine output and serum creatinine have several limitations [2]. Urine output can be affected by a patient's volume status, intravenous fluids, diuretic use, severity of AKI, and type of AKI [4 ▪ ]. Common causes of AKI such as drug-induced acute interstitial nephritis are typically nonoliguric [5].…”

Section: Traditional Acute Kidney Injury Biomarkersmentioning

confidence: 99%

Biomarkers for acute kidney injury in children – where are we now?

Sandokji

Greenberg

2023

Current Opinion in Pediatrics

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Purpose of reviewReview the literature over the last 2 years on commonly evaluated biomarkers of acute kidney injury (AKI) and highlight the findings of these biomarkers.Recent findingsAmong several studied AKI biomarkers, urine neutrophil gelatinase-associated lipocalin (NGAL) and the combination of urine tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) have been recently studied most frequently as diagnostic biomarkers of AKI and for AKI risk stratification. Urine NGAL has continued to show good discriminative value to predict and diagnose AKI in childhood. Urine TIMP-2∗IGFBP7 can provide modest improvement to clinical models of AKI.SummaryPrior research supports that AKI biomarkers may identify AKI at an earlier time point and indicate clinically meaningful tubular injury. More effort should be made to understand if AKI biomarkers can guide treatments and improve outcomes

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Advances in laboratory detection of acute kidney injury

Cited by 11 publications

References 128 publications

Potential Biomarkers for the Earlier Diagnosis of Kidney and Liver Damage in Acute Intermittent Porphyria

Potential Biomarkers for the Earlier Diagnosis of Kidney and Liver Damage in Acute Intermittent Porphyria

A Synopsis of Current Theories on Drug-Induced Nephrotoxicity

Biomarkers for acute kidney injury in children – where are we now?

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