Advances in landscape and related therapeutic targets of the prostate tumor microenvironment

Li, D; Xu, Weidong; Chang, Ying; Xiao, Yu‐Tian; He, Yundong; Ren, Shancheng

doi:10.3724/abbs.2023092

Cited by 10 publications

(3 citation statements)

References 219 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TME of PCa is intricate, which exhibit highly interconnected and complex signaling networks, creating a favorable ecological environment for the survival, development, and metastasis of tumors [ 22 ]. As a “cold” tumor, PCa responds poorly to the regular immune therapies currently used [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Wang,

Feng,

Chen

et al. 2023

Journal of Immunology Research

View full text Add to dashboard Cite

Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells. Resistance to drugs and metastases are potential barriers for prostate cancer endocrine therapy. Although immunotherapy for tumors has developed rapidly in the last few decades, its effectiveness in treating prostate cancer is unsatisfactory. Prostate cancer has a high-expression level of CD47. Therefore, a novel approach for potential immunotherapy may be provided by investigating the relationship among CD47 and the infiltration of immune cells in the prostate carcinoma. Methods. The GEPIA database was utilized to compare the abundance of CD47 in malignant tissues with tissues that were normal. Furthermore, the function of CD47 in prostate carcinoma was assessed by CancerSEA. The association among CD47 and the tumor microenvironment was assessed utilizing the TISCH single cell data database. By using TIMER, the connection among CD47 and immunological invasion of prostate cancer was explored. Moreover, macrophages were cocultured with mouse prostate cancer cell RM-1 blocked by CD47 antibody to observe the changes in phagocytosis efficiency in vitro. Results. Expression level of CD47 is upregulated in prostate carcinoma, and it is closely connected with prostate cancer’s inadequate immune invasion. CD47 antibody blocking promotes macrophage phagocytosis of RM-1. Conclusion. Our research demonstrates a closely relationship among CD47 and the immunological microenvironment of prostate cancer, and blocking CD47 can promote macrophages to phagocytosis of prostate cancer cells. Therefore, CD47 may provide novel strategies for potential immunotherapy of prostate cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Wang,

Feng,

Chen

et al. 2023

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…In conclusion, ADSCs represent a crucial cue in understanding the TME in prostate cancer thus representing a promising therapeutic target 29 . Further studies are needed to fully delineate their role and unravel their therapeutic potential 30 .…”

Section: Introductionmentioning

confidence: 98%

Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro exposure

Cruciani,

Coradduzza,

Balzano

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Adipose-derived stem cells (ADSCs) are promising in regenerative medicine. Their proliferation, survival and activation are influenced by specific signals within their microenvironment, also known as niche. The stem cell niche is regulated by complex interactions between multiple cell types. When transplanted in a specific area, ADSCs can secrete several immunomodulatory factors. At the same time, a tumor microenvironment can influence stem cell behavior, modulating proliferation and their ability to differentiate into a specific phenotype. Whitin this context, we exposed ADSCs to plasma samples derived from human patients diagnosed with prostate cancer (PC), or precancerous lesions (PL), or benign prostatic hyperplasia (BPH) for 4, 7 or 10 days. We then analyzed the expression of main stemness-related markers and cell-cycle regulators. We also measured cytokine production and polyamine secretion in culture medium and evaluated cell morphology and collagen production by confocal microscopy. The results obtained from this study show significant changes in the morphology of ADSCs exposed to plasma samples, especially in the presence of prostate cancer plasma, suggesting important implications in the use of ADSCs for the development of new treatments and application in regenerative medicine.

show abstract

“…Although these findings shed new light on this topic, past and current research has mainly focused on the effects of systemic GC application in PCa patients, epithelial GR signaling, and its impact on tumor progression. However, little is known about the direct GC-mediated effects on GR activity in the tumor-microenvironment (TME), especially in cancer-associated fibroblasts (CAFs), which are known to be even involved in tumor progression [ 9 – 11 ]. Possible functional consequences on the stromal compartment and paracrine effects on the prostate epithelium may influence tumor growth.…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Eigentler,

Handle,

Schanung

et al. 2023

Oncogene

View full text Add to dashboard Cite

Despite significant therapeutic advances in recent years, treatment of metastatic prostate cancer (PCa) remains palliative, owing to the inevitable occurrence of drug resistance. There is increasing evidence that epithelial glucocorticoid receptor (GR) signaling and changes in the tumor-microenvironment (TME) play important roles in this process. Since glucocorticoids (GCs) are used as concomitant medications in the course of PCa treatment, it is essential to investigate the impact of GCs on stromal GR signaling in the TME. Therefore, general GR mRNA and protein expression was assessed in radical prostatectomy specimens and metastatic lesions. Elevated stromal GR signaling after GC treatment resulted in altered GR-target gene, soluble protein expression, and in a morphology change of immortalized and primary isolated cancer-associated fibroblasts (CAFs). Subsequently, these changes affected proliferation, colony formation, and 3D-spheroid growth of multiple epithelial PCa cell models. Altered expression of extra-cellular matrix (ECM) and adhesion-related proteins led to an ECM remodeling. Notably, androgen receptor pathway inhibitor treatments did not affect CAF viability. Our findings demonstrate that GC-mediated elevated GR signaling has a major impact on the CAF secretome and the ECM architecture. GC-treated fibroblasts significantly influence epithelial tumor cell growth and must be considered in future therapeutic strategies.

show abstract

Advances in landscape and related therapeutic targets of the prostate tumor microenvironment

Cited by 10 publications

References 219 publications

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Modulation of adipose-derived stem cell behavior by prostate pathology-associated plasma: insights from in vitro exposure

Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

Contact Info

Product

Resources

About