Advances in Local Ablative Techniques for Breast Cancer

Cheung, Billy Ho-Hung; Co, Michael Tiong-Hong

doi:10.1007/16833_2023_189

Cited by 1 publication

(1 citation statement)

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“…The temperature of the drug carrier system was kept constant by replenishment of ambient water to avoid sample heating upon ultrasonication. The amount of drug release was measured by using UV-Vis spectrophotometer by measuring the absorbance at 490 nm every 20 min (Deng et al, 2016, Jain et al, 2018, Cheung and Neyzari, 1984.…”

Section: Effect Of Ultrasonication On Drug Releasementioning

confidence: 99%

Developing a magnetite/mesoporous silica core /shell system for enhancing the anti-cancer performance of Doxorubicin at low doses for breast cancer treatment

Azab,

Shawky,

El-Sheikh

et al. 2024

Egyptian Journal of Cancer and Biomedical Research

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Background: Doxorubicin (DOX) is one of the main chemotherapies used in breast cancer in the form of many dosage forms such as encapsulation within pegylated liposomes and by injection. Both dosage forms have several side effects, most importantly dilated cardiomyopathy, erythema, acral erythema, and others. Also, DOX acquires resistance in dose-dependent manner by time. Consequently, there is an urgent need for novel approaches and strategies to improve current chemotherapeutic agents' delivery systems including DOX. Nanoparticles (NPs) have found their way in almost all aspects of biomedical applications within the last two decades, such as medical diagnostics, imaging, and drug/gene delivery systems. Mesoporous silica NPs are of great interest as an efficient drug/gene delivery system due to their unique properties. In the same context, magnetic nanoparticles contributed significantly to biomedicine, for their apparent features emerging at the nanoscale. Core/shell nanoparticles have potential characteristics as they incorporate the multiple merits of the used nanoparticles. Aim: Herein, we aimed at developing multifunctional sonochemical method for breast cancer treatment. Materials and Methods: Iron oxide/mesoporous silica/amino; core/shell (M/silica/Amino) was loaded with DOX as a drug delivery system (DDS). The synthesized multifunctional loaded/unloaded DDS was characterized by using TEM, SEM, XRD, FTIR, and TGA. Loading efficiency and release were measured and assessed using different models. Ultra-sonication was applied as externalstimuli of drug release from drug-loaded magnetite silica nanoparticles (M@silica). Evaluation of M@silica@ Amino @DOX system as a nanoscale drug delivery system has been performed regarding safety, payload release, and efficiency of in vitro anti-cancer activity on MCF-7, and normal control MCF10A cell lines. Three time points intervals (1, 4 and 7 days) in triplicate were used to compare the maximum free DOX concentration that affects the cells viability. Molecular evaluation of the (M@SiO2@Amino@DOX), (M@SiO2@Amino), and (free DOX) was performed on the apoptotic biomarkers using real-time PCR as the main mechanism of action of DOX. Results: Potential achievements were obtained for the developed DDS concerning safety, dose adjustment, and mechanism of action compared to the free DOX. The data showed that the concentrations between 10 µg/ml to 25 µg/ml were safe to the cells and are currently applied to compare the effects of the DDS loaded with DOX and free forms regarding the best therapeutic effect, best time, in addition to, the ultrasonication usage in drug release and/or treatment.

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Section: Effect Of Ultrasonication On Drug Releasementioning

confidence: 99%