Advances in local drug delivery technologies for improved rheumatoid arthritis therapy

An, Xiaoran; Yang, Jiapei; Cui, Xiaolin; Zhao, Jiaxuan; Jiang, Chenwei; Tang, Minglu; Dong, Yabing; Lin, Longfei; Li, Hui; Wang, Feihu

doi:10.1016/j.addr.2024.115325

Advanced Drug Delivery Reviews

2024

DOI: 10.1016/j.addr.2024.115325

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Advances in local drug delivery technologies for improved rheumatoid arthritis therapy

Xiaoran An,

Jiapei Yang,

Xiaolin Cui

et al.

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An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes

Ge,

Hu,

et al. 2024

Advanced Materials

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Periodontal disease is a multifactorial, bacterially induced inflammatory disorder characterized by progressive destruction of periodontal tissues. Additionally, diabetes mellitus exacerbates periodontitis, resulting in expedited resorption of periodontal bone. However, methods such as mechanical debridement, anti‐inflammatory medications, and surgical approaches often fail to eradicate local infections and inflammation, complicating the reconstruction of periodontal tissue structures. Consequently, there is an urgent need to devise a novel strategy for managing diabetic periodontal conditions. Here, a multifunctional controlled‐release drug delivery system (GOE1) is developed by encapsulating self‐assembled nanoparticles (consisting of chlorhexidine acetate and epigallocatechin‐3‐gallate) into a hydrogel matrix composed of gelatin methacryloyl and oxidized hyaluronic acid. In vitro experiments demonstrate that the GOE1 hydrogel possesses good antimicrobial, antioxidant and anti‐inflammatory properties, and transgenic sequence genomics further illustrates that IL‐17‐producing RAW 264.7 macrophages are critical for mediating M1/M2 macrophage transition and provide favorable immune microenvironment. In addition, in vivo experiments reveal that GOE1 significantly ameliorates periodontal tissue inflammation and reduces the loss of alveolar bone by reducing inflammatory infiltration and collagen destruction. Overall, the GOE1 hydrogel offers a promising therapeutic option for managing diabetic periodontitis.

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An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes

Ge,

Hu,

et al. 2024

Advanced Materials

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show abstract

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Advances in local drug delivery technologies for improved rheumatoid arthritis therapy

Cited by 1 publication

References 167 publications

An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes

An Immunomodulatory Hydrogel Featuring Antibacterial and Reactive Oxygen Species Scavenging Properties for Treating Periodontitis in Diabetes

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