Advances in Magnetic Nanoparticles for Biomedical Applications

Abstract

Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.

Synthesis and Magnetic Properties of L‐Alanine Capped CoFe2O4 Nanoparticles

“…Therefore, this synthesis expedites the production of MNPs suitable for a wide range of potential applications including biotechnology and data storage via a simple adjustment of the concentration of a low cost, biologically compatible ligand, L‐alanine ,,,…”

Synthesis, Characterization and Application of Chitosan Coated Magnetite Nanoparticles in Drug Delivery

“…Magnetite nanoparticles are widely used in the biomedical applications because of their smaller size, larger surface, and enhanced solubility. The biomedical applications of magnetite nanoparticles include: drug delivery, chemotherapy, magnetofection, hyperthermia, scaffold-based tissue engineering, MRI contrast agents, organ/tissue imaging, theranostic platforms, in vitro bioseparation, bioanalysis, and immunoassays [1][2][3]. Due to the multifunctional properties of the magnetite nanoparticles, they are able to interact with complex cellular functions.…”

Organometallic assembling of chitosan‐Iron oxide nanoparticles with their antifungal evaluation againstRhizopus oryzae

“…Due to hydrophobic forces among bare NPs the particles assemble and form large clusters which expands surface area to volume ratio of the NPs . The surface coating of magnetic NPs is indispensable in the interest of avoiding agglomeration and enhancing the potential of NPs in several areas of applications . Furthermore the chemico‐physical properties of NPs depend on the nature of the surface coating material …”