Advances in membrane-based chiral separation

Nanocrystalline Porous Materials for Chiral Separation: Synthesis, Mechanisms, and Applications

“…This means that it is impossible to predict the fitness of the given system to a particular substrate and the exact mechanism that causes this differential selectivity. 3 At its inception, the concept of enantioselection was promptly acknowledged as an innate geometrical determinant that delineates the disparity between two enantiomers in the realm of asymmetric processing. Therefore, spatial effects at the molecular level are usually taken into account when analyzing transition states for chiral recognition based on the three-point adsorption (TPA) model.…”

“…Even though it has been favored many times by the Nobel Prize, enantioselective catalysis or separation is still an empirical science. This means that it is impossible to predict the fitness of the given system to a particular substrate and the exact mechanism that causes this differential selectivity . At its inception, the concept of enantioselection was promptly acknowledged as an innate geometrical determinant that delineates the disparity between two enantiomers in the realm of asymmetric processing.…”

“…Its significance reverberates across various domains, notably encompassing pharmaceuticals, agrochemicals, and other categories of fine chemicals. Such prominence renders it a veritable “popular” element within these spheres. , Following the notoriety of the thalidomide tragedy during the 1950s and 1960s, the prevalence of chiral drugs across diverse therapeutic classes and their substantial market shares compelled scientists to seek efficacious methods of gaining access to optically pure enantiomers. − Presently, there are three main ways to obtain it, including extraction of natural chiral drugs, asymmetric synthesis, and chiral separation . Notably, chiral separation garners favor owing to its capacity for quantitative yield, environmental compatibility, and heightened atom economy. , Chiral materials have demonstrated significant prowess in stability, separation efficiency, and mechanistic investigations, thereby furnishing the indispensable chiral milieu requisite for effective separations. − This observation finds ample support in the prior utilization of a diverse array of materials, ranging from cyclodextrins (CDs), crown ethers, proteins, DNA, and polysaccharide derivatives to macrocyclic antibiotics .…”

Metal/covalent–organic framework based thin film nanocomposite membranes for advanced separations

“…1–3 These separations present exceptional advantages like high energy efficiency, customized fractionation, scalability, and unparalleled versatility, enabling continuous and momentous advancements in these critical fields. 4 At present, synthetic membranes are primarily fabricated based on cost-effective polymers, in which polyamides are one typical category of dominant membrane materials. 5 Polyamide (PA) membranes are chiefly processed in the configuration of TFC membranes, comprising a thin PA film, a porous substrate and an underlying mechanically stable fabric.…”

Chiral Covalent Organic Frameworks as Promising Materials for Racemate Resolution

“…Nowadays, chiral separation has become the principal method for obtaining pure enantiomers. Among the commonly used chiral separation techniques, including chromatography, membrane separation, crystallization, and kinetic resolution, chromatography stands out as an effective tool for analytical enantiomer separation. On the other hand, membrane separation has gained popularity for large-scale enantiomers resolution, due to its simple operation, low energy consumption and environmental friendliness …”