2019
DOI: 10.1016/j.tibtech.2019.04.006
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Advances in Microfluidic Blood–Brain Barrier (BBB) Models

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Cited by 183 publications
(161 citation statements)
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“…[9] Starting from relatively simple approaches based on artificial membrane permeability assays [10] and transwell assays, [11] research efforts have been moved to the development of 2D [12][13][14][15][16][17][18] and 3D [19][20][21][22][23][24][25][26][27][28] microfluidic lab-on-a-chip devices that could properly mimic the natural BBB and the relative interaction with drugs. [29,30] However, to date, the technological limits of the available fabrication approaches do not allow reproducing at the natural dimensional scale the brain microcapillaries, that are characterized by a diameter of about 10-20 µm. [5] Furthermore, there are no examples of microfluidic systems that present both a realistic barrier model and an accurate 3D model of the pathological milieu.…”
Section: Doi: 101002/admt202000540mentioning
confidence: 99%
“…[9] Starting from relatively simple approaches based on artificial membrane permeability assays [10] and transwell assays, [11] research efforts have been moved to the development of 2D [12][13][14][15][16][17][18] and 3D [19][20][21][22][23][24][25][26][27][28] microfluidic lab-on-a-chip devices that could properly mimic the natural BBB and the relative interaction with drugs. [29,30] However, to date, the technological limits of the available fabrication approaches do not allow reproducing at the natural dimensional scale the brain microcapillaries, that are characterized by a diameter of about 10-20 µm. [5] Furthermore, there are no examples of microfluidic systems that present both a realistic barrier model and an accurate 3D model of the pathological milieu.…”
Section: Doi: 101002/admt202000540mentioning
confidence: 99%
“…MFs neural interfaces have immense potential in clinical medicine and basic neuroscience research. [ 59 ] Moreover, MFs techniques and principles have been applied to isolate brain tissue culture for studies. [ 59 ] Recently, the MFs neural probes have led to the emergence of wireless flexible platforms to allow monitoring of natural movement and behavior while simultaneously minimizing chronic immune‐reactive responses in the neural tissue.…”
Section: Biomedical Diagnosticsmentioning
confidence: 99%
“…[ 59 ] Moreover, MFs techniques and principles have been applied to isolate brain tissue culture for studies. [ 59 ] Recently, the MFs neural probes have led to the emergence of wireless flexible platforms to allow monitoring of natural movement and behavior while simultaneously minimizing chronic immune‐reactive responses in the neural tissue. [ 60,61 ] However, increased efforts are necessary to obtain improved and ready use of these devices in neurology.…”
Section: Biomedical Diagnosticsmentioning
confidence: 99%
“…Similarly, researchers have engineered neural cell culture systems to reproduce the complicated cerebral environment, comprising the BBB and the different cell populations-neurons and glial cells [48][49][50]. As for the liver and the gut, the strategies most considered so far are organ-on-a-chip devices.…”
Section: Gut-liver-brain Communicationmentioning
confidence: 99%