Advances in Microfluidic Materials, Functions, Integration, and Applications

Nge, Pamela N.; Rogers, Chad I.; Woolley, Adam T.

doi:10.1021/cr300337x

Cited by 795 publications

(640 citation statements)

References 365 publications

(780 reference statements)

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“…Microfluidic device prototyping for proof-of-principle demonstration typically utilizes hot embossed or injection molded plastics 1,17 or polydimethylsiloxane (PDMS). 18,19 In either case, two or more individually fabricated layers are bonded together to form a completed device.…”

Section: Microfluidicsmentioning

confidence: 99%

3D printed microfluidic devices with integrated valves

2015

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We report the successful fabrication and testing of 3D printed microfluidic devices with integrated membrane-based valves. Fabrication is performed with a low-cost commercially available stereolithographic 3D printer. Horizontal microfluidic channels with designed rectangular cross sectional dimensions as small as 350 μm wide and 250 μm tall are printed with 100% yield, as are cylindrical vertical microfluidic channels with 350 μm designed (210 μm actual) diameters. Based on our previous work [Rogers et al., Anal. Chem. 83, 6418 (2011)], we use a custom resin formulation tailored for low non-specific protein adsorption. Valves are fabricated with a membrane consisting of a single build layer. The fluid pressure required to open a closed valve is the same as the control pressure holding the valve closed. 3D printed valves are successfully demonstrated for up to 800 actuations.

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Section: Microfluidicsmentioning

confidence: 99%

3D printed microfluidic devices with integrated valves

2015

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“…Mark et al (2010), Iliescu et al (2012), Nge et al (2013), Temiz et al (2015), Kim and Meng (2015) The platform presented here is our attempt at creating a platform that can be used as widely as possible, but it is not possible to offer all advantages of other platforms, without any of their drawbacks. One of the advantages of this platform, a very thin channel wall, also is one of its drawbacks.…”

Section: Discussionmentioning

confidence: 99%

A versatile technology platform for microfluidic handling systems, part I: fabrication and functionalization

Groenesteijn

Boer

Lötters

et al. 2017

Microfluid Nanofluid

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often have to be connected using (external) fluidic interconnects. This way, the fluidic interconnects will have a relatively large volume, resulting in slow response times and requiring large sample sizes.To make the ideal integrated microfluidic handling system, one fabrication process should allow many different microfluidic devices for all kinds of applications to be integrated on the same chip. The functional channels of the devices, the interconnect channels and the required interfacing electronics should be integrated on the same substrate without restricting the design options for each device.Different applications pose different demands on the fabricated system. To avoid leakage and wear, the channel walls should be mechanically strong, chemically inert and leak tight for both liquids and gasses in a large temperature range. It should be possible to locally release the channel (completely or partially) from the substrate, e.g. for thermal isolation or freedom of movement. It is required to integrate transducer structures for actuation and measurement of the devices. This can be anything from metal tracks to piezoelectric or magnetic materials or optical waveguides. Functionalization of the inside of the channel, e.g. with a catalyst or with specific coatings for (bio)chemical reactions or adhesion should be possible. Multiple channels should be able to cross each other or run inside each other. Interface electronics should be integrated directly on the chip or package to reduce noise and other parasitic effects.To be able to transfer proof-of-concepts to commercial devices, it should not only be possible to fabricate low-volume research devices, but it should also be possible to scale up the fabrication to industrial low-cost, high-volume processing in foundries. Last, and certainly not least, it should be straightforward to design the optimal fluidic element with respect to shape and size, for any application. AbstractMany microfluidic devices are made using specialized fabrication processes, limiting the ability to integrate those devices on the same chip. In this paper, a versatile technology platform is presented that allows for integration of many different devices. It provides a method to design channels in a wide range of sizes and shapes with different functionalization options in close proximity to the fluid in the channels. The latter includes release of the channels for thermal isolation or mechanical movement and metal or piezoelectric layers for actuation and read-out. The channel walls are made using silicon-rich silicon nitride to provide durable, strong, chemically inert and thermally stable channels directly below the substrate surface .

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“…4 Recently, there has been increasing interest in the use of micro total analysis systems (μ-TAS) as miniaturized analytical systems for the analysis of small sample amounts. 5,6 The use of such a μ-TAS device enables the miniaturization of analytical systems, the reduction of the amount of samples necessary for analysis, and a decrease in the analysis time because each chemical analytical system element is integrated on a single chip using the micromachining technique. UV absorbance detection, 7 laser-induced fluorescence, 8,9 electrochemical detection 10,11 as well as other techniques have been used as the basis for μ-TAS detectors.…”

Section: Introductionmentioning

confidence: 99%

Development of a High-Density Microplasma Emission Source for a Micro Total Analysis System

et al. 2017

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To achieve a highly sensitive and onsite analysis of a small amount samples, a microplasma-based micro total analysis systems (μ-TAS) device was developed. A dielectric barrier discharge (DBD) that can generate a stable plasma at atmospheric pressure was generated in a microchip and used as the plasma source. The use of DBD suppresses the temperature rise of the electrodes and enables operation for long times because of a reduction of the electrode damage due to suppression of the current via dielectric interposing between the electrodes. It is expected that the analytical system can be miniaturized because helium plasma is generated in the microchannel contained in the microchip. Emissions from gaseous Cl, Br, and I were analyzed using the plasma source, and it was found that the detection limits for these analytes were 0.22, 0.18, and 0.14 ppm, respectively. The calibration curves for gaseous Cl, Br, and I were also plotted obtaining correlation coefficients of 0.975, 0.955 and 0.986, respectively, and showing good linearity for the developed plasma source.

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Advances in Microfluidic Materials, Functions, Integration, and Applications

Cited by 795 publications

References 365 publications

3D printed microfluidic devices with integrated valves

3D printed microfluidic devices with integrated valves

A versatile technology platform for microfluidic handling systems, part I: fabrication and functionalization

Development of a High-Density Microplasma Emission Source for a Micro Total Analysis System

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