Advances in microwave hyperthermia of large superficial tumors

Maccarini, Paolo F.; Rolfsnes, Hans O.; Neumann, Drexel A.; Johnson, J.; Juang, Titania; Stauffer, Paul R.

doi:10.1109/mwsym.2005.1517073

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…Following initial optimization of the radiation pattern of DCC square slot apertures by Rossetto and others (24–26, 28, 29, 62), Maccarini et.al. (63–65) demonstrated the ability to produce similar peripherally enhanced heating patterns that extend out to the perimeter of triangular or other polygon shapes as well as square apertures. Furthermore, the microstrip feedlines that distribute power from RF connectors on one edge of the PCB were optimized to include tuning stubs at each DCC aperture feedpoint and the original open microstrip design was replaced with coplanar waveguide buried between two ground planes to reduce losses in the PCB structure and eliminate radiation into air behind the antenna array (66).…”

Section: Conformal Microwave Array Applicator For Large Area Chestmentioning

confidence: 99%

Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence

Stauffer

Maccarini

Arunachalam

et al. 2010

International Journal of Hyperthermia

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Purpose This article summarizes the evolution of microwave array applicators for heating large area chestwall disease as an adjuvant to external beam radiation, systemic chemotherapy, and potentially simultaneous brachytherapy. Methods Current devices used for thermotherapy of chestwall recurrence are reviewed. The largest conformal array applicator to date is evaluated in four studies: i) ability to conform to the torso is demonstrated with a CT scan of a torso phantom and MR scan of the conformal waterbolus component on a mastectomy patient; ii) Specific Absorption Rate (SAR) and temperature distributions are calculated with electromagnetic and thermal simulation software for a mastectomy patient; iii). SAR patterns are measured with a scanning SAR probe in liquid muscle phantom for a buried coplanar waveguide CMA; and iv) heating patterns and patient tolerance of CMA applicators are characterized in a clinical pilot study with 13 patients. Results CT and MR scans demonstrate excellent conformity of CMA applicators to contoured anatomy. Simulations demonstrate effective control of heating over contoured anatomy. Measurements confirm effective coverage of large treatment areas with no gaps. In 42 hyperthermia treatments, CMA applicators provided well-tolerated effective heating of up to 500cm2 regions, achieving target temperatures of Tmin=41.4±0.7°C, T90=42.1±0.6°C, Tave=42.8±0.6°C, and Tmax=44.3±0.8°C as measured in an average of 90 points per treatment. Summary The CMA applicator is an effective thermal therapy device for heating large-area superficial disease such as diffuse chestwall recurrence. It is able to cover over three times the treatment area of conventional hyperthermia devices while conforming to typical body contours.

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Section: Conformal Microwave Array Applicator For Large Area Chestmentioning

confidence: 99%

Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence

Stauffer

Maccarini

Arunachalam

et al. 2010

International Journal of Hyperthermia

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“…While hyperthermia array applicators [18], [19] with sophisticated control systems [20], [21] offer advanced targeting for treating different cancers, a range of complementary single element designs continue to offer simple solutions [22]. Various 434 MHz single element applicator types have been reported and of the peak SAR or temperature values is used to compare the penetration depths for the following references.…”

Section: Compact Patch Antenna For Electromagnetic Interaction With Hmentioning

confidence: 99%

Compact Patch Antenna for Electromagnetic Interaction With Human Tissue at 434 MHz

Curto¹,

McEvoy²,

Bao

et al. 2009

IEEE Trans. Antennas Propagat.

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Single element loop, dipole and conventional square patch antennas have been used as hyperthermia applicators in the treatment of cancerous human cells at superficial depths inside the body. A smaller novel patch antenna in very close proximity to a phantom tissue model produces an enhanced specific absorption rate pattern without significant frequency detuning or impedance mismatch. The new patch increases its coupling aperture by supporting a combination of resonances that are also typical for loop, dipole and square patch antennas. For computation efficiency and clarity in the synthesized hyperthermia treatment conditions, simplified planar tri-layered tissue models interfaced with a waterbolus are used to study the permittivity loading on the antennas and the resultant specific absorption rates.

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“…Microwave heating has been extensively investigated in many fields ranging from industry [1] to medicine [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…However, these invasive methods are often undesirable due to the tumor location or the discomfort of patients. Stauffer's group recently proposed a dual concentric conductor printed circuit board array combined with Archimedean spiral microstrip antennas driven at either 915 or 433MHz [3]. The system may be beneficial to treat large superficial disease and monitor temperature.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast with the large waveguide, current sheet applicators [5] are light, and convenient in use, but every single applicator covers only a small area. Applicators using microstrip designs also have received attention since they are compact, lightweight and can be employed either as single [6] or as multielement applicators [3]. For example, Gelvich et al [6] focused on hyperthermia treatment at frequencies of 434, 70, 40 and 27MHz in contact flexible microstrip applicators (CFMA) where two antenna types are used: inductive antenna with a radiating plane electrical dipole at microwave, and coplanar capacitive antennas providing depression of the normal component of the electrical field in the VHF and HF range.…”

Section: Introductionmentioning

confidence: 99%

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Microwave heating by using flat LHM lens

Gong

Wang

2008

2008 International Workshop on Metamaterials

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Microwave heating system for hyperthermia by using four flat LHM lenses orthogonally-deployed around the heating region is proposed and simulated. For the process of heating a 6mm-diameter tumor in homogeneous lossy dielectric medium, our 2-D FDTD simulations indicate that microwave energy can be concentrated tightly inside the tumor. Also the temperature distribution is derived through bio-heat equation (BHE), which has been solved by finite differential approach. Due to the admiring focusing properties of LHM lens, the temperature inside the tumor may rise from 37℃ to more than 42.65℃ during one hour with average input power density of 1.60 W/cm at 6GHz, while the temperature of normal tissue keeps well below 42℃ as the requirement of hyperthermia.

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Advances in microwave hyperthermia of large superficial tumors

Cited by 8 publications

References 9 publications

Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence

Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence

Compact Patch Antenna for Electromagnetic Interaction With Human Tissue at 434 MHz

Microwave heating by using flat LHM lens

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