Advances in modern research on pharmacological effects of Radix Rehmanniae

Luo, Chunyu; Qin, Shuzhi; Liang, Pu-Lin; Ling, Wenpei; Zhao, Chengguo

doi:10.1063/5.0020348

Cited by 6 publications

(6 citation statements)

References 3 publications

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“…Rehmannioside A can improve immune activity. 32 Rehmapicrogenin has been shown to exhibit an anti-inflammatory effect by significantly inhibiting NO production. 33 Oligosaccharides can enhance the proliferation of skeletal myoblasts, protect and induce differentiation of adipose tissue-derived mesenchymal stromal cells and bone marrow mesenchymal stem cells.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Combination of Internal Extractive Electrospray Ionization Mass Spectrometry and Statistical Analysis for High-Throughput Molecular Differentiation of Rehmannia glutinosa Samples

Xu,

Yu,

et al. 2023

J. Am. Soc. Mass Spectrom.

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Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey. is a perennial herb of the Scrophulariaceae family, which has long enjoyed a good reputation in China, and has a wide range of pharmacological effects and clinical applications. The place of origin is an important factor affecting the chemical composition of R. glutinosa, resulting in different pharmacological effects. Herein, internal extractive electrospray ionization mass spectrometry (iEESI-MS) combined with statistical techniques was established for high-throughput molecular differentiation of different R. glutinosa samples. Dried and processed R. glutinosa samples from four different places of origin were analyzed by iEESI-MS with high throughput (>200 peaks) and rapidness (<2 min/sample) without sample pretreatment. Clear separation models created by OPLS-DA were then established for distinguishing the places of origin of dried and processed R. glutinosa by using the obtained MS data. In addition, the molecular differences between the pharmacological effects of dried and processed R. glutinosa were also investigated by OPLS-DA, and 31 different components were screened out. This work provides a promising method for evaluating the quality of traditional Chinese medicines and studying the biochemical mechanism of processing.

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Section: ■ Results and Discussionmentioning

confidence: 99%

“…Specifically, catalpol has the effects of antitumor, blood pressure reduction, and neuroprotection. Rehmannioside A can improve immune activity . Rehmapicrogenin has been shown to exhibit an anti-inflammatory effect by significantly inhibiting NO production .…”

Section: Resultsmentioning

confidence: 99%

Combination of Internal Extractive Electrospray Ionization Mass Spectrometry and Statistical Analysis for High-Throughput Molecular Differentiation of Rehmannia glutinosa Samples

Xu,

Yu,

et al. 2023

J. Am. Soc. Mass Spectrom.

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“…In both LDD and ZDD, Radix Rehmanniae is the monarch drug, which mainly contains iridoids and its glycoside, violet ketones, flavonoids, saccharides, amino acid, and volatile oils (Liu, Yin, et al, 2020). Many studies focusing on the pharmacological effects of Radix Rehmanniae suggested that it can regulate the level of estrogen and exhibit estrogen-like activity (Luo et al, 2020).In recent laboratory research, Tian and co-workers reported that both water and ethanol extracts of Radix Rehmanniae promoted the secretion of estradiol from ovarian granulosa cells and the expression of estrogen receptor α (ERα) on spleen cells in vitro (Tian et al, 2017). Furthermore, another laboratory study conducted by Zhao et al demonstrated that rehmapicrogenin contributed to the estrogenic effects of Radix Rehmanniae.…”

Section: Tcm Compounds and Their Preparations Based On Nourishing Kidneymentioning

confidence: 99%

Clinical research on traditional Chinese medicine treatment for bacterial vaginosis

Zhao

et al. 2021

Phytotherapy Research

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Bacterial vaginosis (BV) is a common disease among women of reproductive age, with a serious impact on their daily life and health. At present, the most common treatment for BV is to take antibiotics, which results in good short‐term treatment effects, but poor long‐term effects. Traditional Chinese medicine (TCM) has been used to treat BV for over a millennium, with little risk of triggering drug resistance and adverse effects. Based on syndrome differentiation, there are three oral TCM treatment strategies for BV, including invigorating spleen, clearing dampness and heat, and nourishing kidney. The oral TCM prescriptions, such as Yi Huang decoction, Longdan Xiegan decoction, Zhibai Dihaung decoction, and so on are commonly used. Topical TCM treatment is also popular in China. According to the research results of pharmacological effects of active TCM ingredients, the most potential mechanisms of TCM for BV treatment are immune‐enhancement effects, antibacterial activity, and estrogen‐liked effects. Nonetheless, the multi‐constituent of herbs may result in possible disadvantages to BV treatment, and the pharmacological mechanisms of TCM need further study. Here, we provide an overview of TCM compounds and their preparations used for BV, based on the pathogenesis and the potential therapeutic mechanisms, therefore providing a reference for further studies.

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“…Recent pharmacological studies have reported that R. glutinosa possesses anti-oxidant, hypoglycemic, anti-inflammatory, anti-cancer, and immunoregulatory effects [7]. In addition, processed R. glutinosa roots protect against aging, oxidation, and cancer and improve marrow and essence [8]. However, steam processing could alter the contents of some compounds, thereby affecting pharmacological activity [9].…”

Section: Introductionmentioning

confidence: 99%

Standardization of Rehmannia glutinosa (Gaertn.) DC. steam processing and evaluation of its chemical, anti-oxidant, and anti-inflammatory properties

et al. 2023

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Rehmannia glutinosa (Gaertn.) DC., belonging to the family Scrophulariaceae, is an important medicinal herb cultivated in East Asia. Traditionally, R. glutinosa is steam processed to increase its efficacy in treating various ailments such as diabetes, hematinic deficiencies and adrenal disorder. However, standardization of processed R. glutinosa is highly needed to increase its quality to fulfill global market demand that is safe and possess high level of efficacy. Therefore, this study aimed to optimize the R. glutinosa steam processing methods by evaluating some key parameters such as steaming temperature, number of steaming times, steaming duration, and additive supplementation. R. glutinosa samples were steam processed at different temperatures (100 °C, 110 °C, and 120 °C), various steaming times (1 to 5 times), several steaming duration (1 to 4 h), and additives supplementation (rice wine, 5% EtOH, 10% EtOH, 20% EtOH, 30% EtOH, and 40% EtOH). As the result, 2 h, 3 replications, and supplementation with 20% EtOH at 120 °C were identified as the optimal conditions for R. glutinosa steam processing. Optimized processed R. glutinosa (SPRR 20%EtOH) resulted in significantly higher content of 5-HMF (7648.60 ± 150.08 µg/g) and iso-verbacoside (203.80 ± 10.72 µg/g) compared with unprocessed R. glutinosa (UPR). Compared to those of other samples, SPRR 20% EtOH samples had higher total flavonoid (55.36 ± 1.68 mg/g) and phenolic (69.24 ± 4.56 mg/g) contents and stronger DPPH antioxidant activity (56%). Furthermore, SPRR 20% EtOH had excellent anti-inflammatory activity, as evidenced by the suppression of inducible nitric oxide synthase (iNOS) caused by activation of nuclear factor-κB (NF-κB) through p-p65 pathway in LPS-stimulated RAW 264.7 cells. These findings will provide a basis towards industrialization of R. glutinosa processing technology that will be very helpful for oriental medication field.

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Advances in modern research on pharmacological effects of Radix Rehmanniae

Cited by 6 publications

References 3 publications

Combination of Internal Extractive Electrospray Ionization Mass Spectrometry and Statistical Analysis for High-Throughput Molecular Differentiation of Rehmannia glutinosa Samples

Combination of Internal Extractive Electrospray Ionization Mass Spectrometry and Statistical Analysis for High-Throughput Molecular Differentiation of Rehmannia glutinosa Samples

Clinical research on traditional Chinese medicine treatment for bacterial vaginosis

Standardization of Rehmannia glutinosa (Gaertn.) DC. steam processing and evaluation of its chemical, anti-oxidant, and anti-inflammatory properties

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