Advances in modified hyaluronic acid-based hydrogels for skin wound healing

Ding, Yanwen; Wang, Ze-Yu; Ren, Zi-Wei; Zhang, Xu-Wei; Wei, Daixu

doi:10.1039/d2bm00397j

Cited by 94 publications

(77 citation statements)

References 246 publications

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“…Several types of hydrogels have been widely utilized for the intratumoral delivery of Res [ 32 , 39 , 40 ]. Several groups have reported the good biocompatibility of crosslinked HA using carbodiimide series, (metha)acrylate series, diglycidyl ether, etc [ [41] , [42] , [43] ]. Among them, click-crosslinkable hydrogels remain in liquid form prior to injection but solidify through click-crosslinking during injection, allowing for the generation of a minimally invasive drug depot.…”

Section: Discussionmentioning

confidence: 99%

Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer

Shin

Kim

et al. 2022

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer

Shin

Kim

et al. 2022

Materials Today Bio

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“…However, one of the limitations is their pH sensitivity, which makes Schiff‐based hydrogels unstable under acidic conditions, hindering their practical applications in certain disease where the pH is usually slightly acidic. [ 60,61 ]…”

Section: Preparation Methods Of Injectable Ha‐based Hydrogelsmentioning

confidence: 99%

Hyaluronic Acid‐Based Injectable Hydrogels for Wound Dressing and Localized Tumor Therapy: A Review

Yang

Wang

Peng

et al. 2022

Advanced NanoBiomed Research

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Hyaluronic acid (HA)‐based hydrogels are regarded as ideal candidates for wound dressing and localized cancer treatment due to the excellent biocompatibility, potential targeting property, and highly adaptable structure for modulated functionalities. Among the numerous advantages, the injectable property is probably one of the most important factors that determines the therapeutic efficiency of HA‐based hydrogels as wound dressings because it enables to complete filling of wound sites, in situ encapsulation of any bioactive molecule, and sufficient adherence to wounds. Meanwhile, HA‐based injectable hydrogels can be used as localized drug delivery systems for cancer therapy with significantly compromised systematic side effects. Therefore, there is clearly considerable scope to compose a timely review on this hot subject of research. However, few reviews, as per knowledge, focus on this topic. For this purpose, the recent notable efforts made on the use of HA‐based injectable hydrogels as new‐type wound dressings and localized drug delivery systems with a focus on chemistry adopted to achieve desirable properties and functions for optimal performances are summarized. The useful information and guidelines summarized here are believed to promote next generation and clinical translations of HA‐based injectable hydrogels with greater therapeutic efficiency for wound dressing and localized tumor therapy.

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“…HA is a natural linear anionic polysaccharide with many distinct properties such as good biocompatibility and biodegradability, native biofunctionality, hydrophilicity, and non-immunoreactivity. ( Ding et al, 2022 ) These properties contribute to its utilization as a promising candidate in clinical ophthalmology. HA has been used as an artificial tear ingredient to treat dry eyes, as well as a viscoelastic agent for cataract surgery.…”

Section: Sealants Of Natural Originmentioning

confidence: 99%

Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment

Zheng

Wen

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Rhegmatogenous retinal detachment (RRD) is the most common retinological emergency that can cause blindness without surgical treatment. RRD occurs when liquefied vitreous accumulates between the neurosensory retina and the retinal pigment epithelium via retinal breaks, which are caused by the separation of the vitreous from the retina with aging. Currently, the main treatment option is pars plana vitrectomy, which involves surgical removal of the vitreous and laser photocoagulation around retinal breaks to generate firm chorioretinal adhesion, as well as subsequent filling of the vitreous cavity with long-lasting substitutes (expansile gas or silocone oil) to prevent the connection between the subretinal space and the vitreous cavity via the breaks before the chorioretinal adhesion firm enough. However, the postoperative face-down position and the not very satisfactory first retinal reattachment rate place a heavy burden on patients. With the development of technology and materials engineering, researchers have developed biomaterials that can be used as a retinal patch to seal retinal breaks and prevent the connection of subretinal space and vitreous cavity via breaks, thus replacing the long-lasting vitreous substitutes and eliminating the postoperative face-down position. Preclinical studies have demonstrated that biomaterial sealants have enough biocompatibility and efficacy in the in vitro and in vivo experiments. Some sealants have been used in clinical trials on a small scale, and the results indicate promising application prospects of the biomaterial sealants as retinal patches in the repair of RRD. Herein, we review the recent advances in biomaterials as retinal patches for the repair of RRD, focusing on the biomaterial categories, methods, and procedures for sealing retinal breaks, as well as their biocompatibility and efficacy, current limitations, and development perspectives.

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Advances in modified hyaluronic acid-based hydrogels for skin wound healing

Abstract: Hyaluronic acid (HA) is a natural linear anionic polysaccharide with many unique characteristics such as excellent biocompatibility and biodegradability, native biofunctionality, hydrophilicity, and non-immunoreactivity. HA plays crucial roles in numerous...

Cited by 94 publications

References 246 publications

Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer

Injectable click-crosslinked hydrogel containing resveratrol to improve the therapeutic effect in triple negative breast cancer

Hyaluronic Acid‐Based Injectable Hydrogels for Wound Dressing and Localized Tumor Therapy: A Review

Advances in biomaterials as a retinal patch for the repair of rhegmatogenous retinal detachment

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