Advances in Morphology

Dressler, Wolfgang U.; Prinzhorn, Martin; Rennison, John R.

doi:10.1515/9783110886733

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Changing genetic world of IVF, stem cells and PGD. A. Early methods in research

Edwards¹

2005

Reproductive BioMedicine Online

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Genetics proved essential to introduce IVF, preimplantation diagnosis (PGD) and embryo stem cells in the 1960s. Its small input in early years was confined to aspects such as timing follicle growth and ovulation. Modest understanding in the mid- to late 1980s, mostly on studies in mice, involved the actions of single genes and the balance between maternal and zygotic transcripts in preimplantation stages. Human IVF began after human oocytes were matured in vitro, and their meiotic chromosomes analysed. Their fertilization in vitro led to PGD and embryo stem cells. Unlike mouse embryos, most human embryos failed to implant, so the best had to be selected to improve IVF pregnancy rates. Initially, faster-growing embryos proved superior. Later, patterns of polarized nucleoli in pronuclei, the degree of blastomere fragmentation and growth of embryos in vitro to blastocysts provided excellent markers. Single cells could be isolated from embryos using micromanipulation. Stem cells from inner cell mass, a branch of IVF, differentiated into immortal stem cell lines in vitro if disaggregated. They formed virtually all body tissues in blastocysts cultured intact or when injected singly into recipient blastocysts. Later, the genetic controls of ES cell differentiation were assessed, together with factors switching them along specific differentiation pathways. Marker genes identified ES cells differentiating into various tissues.

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Changing genetic world of IVF, stem cells and PGD. A. Early methods in research

Edwards¹

2005

Reproductive BioMedicine Online

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The Modular Architecture of Grammar

Sadock

2011

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Modular grammar postulates several autonomous generative systems interacting with one another as opposed to the prevailing theory of transformational grammar where there is a single generative component – the syntax – from which other representations are derived. In this book Jerrold Sadock develops his influential theory of grammar, formalizing several generative modules that independently characterize the levels of syntax, semantics, role structure, morphology and linear order, as well as an interface system that connects them. Multi-modular grammar provides simpler, more intuitive analyses of grammatical phenomena and allows for greater empirical coverage than prevailing styles of grammar. The book illustrates this with a wide-ranging analysis of English grammatical phenomena, including raising, control, passive, inversion, do-support, auxiliary verbs and ellipsis. The modules are simple enough to be cast as phrase structure grammars and are presented in sufficient detail to make descriptions of grammatical phenomena more explicit than the approximate accounts offered in other studies.

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Advances in Morphology

Cited by 2 publications

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Changing genetic world of IVF, stem cells and PGD. A. Early methods in research

Changing genetic world of IVF, stem cells and PGD. A. Early methods in research

The Modular Architecture of Grammar

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