Advances in multimodality molecular imaging

Zaidi, Habib; Prasad, Rameshwar

doi:10.4103/0971-6203.54844

Cited by 43 publications

(27 citation statements)

References 30 publications

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“…10,[36][37][38] Optical imaging has preceded all other imaging modality, having been widely used for many centuries. It also has been shown to have sensitivity, specificity, and resolution unparalleled by other biomedical imaging methods.…”

Section: Nuclear and Optical Imaging Combinationsmentioning

confidence: 99%

“…However, it is difficult to accurately quantify fluorescence signals in living subjects, particularly in deep tissues due to intrinsic tissue signal attenuation and autofluorescence arising from organic components and absorbed dietary constituents. 10,38 Currently, high-resolution PET has been routinely used in the clinic for staging and evaluating many types of cancer. 14,39 However, accurate localization of PET probe uptake can be very difficult in some cases due to the absence of identifiable anatomic structures, particularly in the abdomen.…”

Section: Nuclear and Optical Imaging Combinationsmentioning

confidence: 99%

“…Combinations of multiple modalities, especially with multifunctional probes, can yield complementary information and offer synergistic advantages over any modality alone. [8][9][10][11] The focus of this chapter is to describe the current developments in multifunctional probes for multimodality imaging of cancer.…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Probes for Multimodality Imaging of Cancer

Liu¹,

Chen²,

Ai³

2012

Molecular Imaging Probes for Cancer Research

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Section: Nuclear and Optical Imaging Combinationsmentioning

confidence: 99%

Section: Nuclear and Optical Imaging Combinationsmentioning

confidence: 99%

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Multifunctional Probes for Multimodality Imaging of Cancer

Liu¹,

Chen²,

Ai³

2012

Molecular Imaging Probes for Cancer Research

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“…The pioneering research of Brownell and Sweet at the Massachusetts General Hospital in 1953 allowed for the first positron detector to study brain function in humans. Since then the imaging scientists Kuhl, Pogossian, Wolf, Sokoloff, Phelps, Di Chiro, Alavi and Wagner have made further contributions to the future development of clinical PET imaging [289].…”

Section: Pet Imagingmentioning

confidence: 99%

Squaryl Molecular Metaphors – Application to Rational Drug Design and Imaging Agents

Kitson¹

2017

J Diagn Imaging Ther

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Molecular Metaphors is the application of squaryl building blocks towards creative functional group chemistry to produce lead compounds and imaging agents. This strategy is applied to rational drug design and to various imaging agents that would normally contain conventional functional group chemistry. These, include carboxylic acids, α-amino acids, peptide bonds and phosphonates. Moreover, the squaryl metaphor is a precursor to complex organic molecules involving functional group interchange (FGI) and rearrangements. This article discusses the application of these metaphors in the area of neurochemistry, especially NMDA receptors. An important area of drug design is the inhibition of angiotensin II enzyme by the use of losartan. This commercial drug contains a tetrazole moiety that can be modified using the squaryl group to give a semisquarate derivative. These concepts can extend to the semisquarate of ibuprofen. Moreover, a discussion on peptidomimetics regarding the substitution of the peptide bond for squaramide allows for a change in the biological properties due to modification at the peptide bond. Furthermore, the topic on how squaryl metaphors can be exploited primarily by the central 1,3-hydroxyamide sequence to the generation of a novel class of HIV protease inhibitors. Also, squaryl metaphors can be used to develop potential inhibitors of glutathione and novel anti-migraine drugs. The discussion continues on the design of anticancer drugs: in particular, a novel class of metalloproteases, including phosphonates for semisquaramides, leading to squaryl nucleosides. This review concludes with the application of squaryl metaphors in the design of positron emission tomography (PET) and magnetic resonance imaging (MRI) agents towards theranostics. describe the ability of individual functional chemical groups to mimic other moieties [2,3]. KeywordsErlenmeyer rationalised these concepts and categorised isosteres into atoms, ions and molecules based on the valence level of electrons [4]. A further understanding by Friedman led to the term bioisosterism to include all atoms and molecules that fit the broadest definition of isosteres [5]. This approach was independent of whether the drug was an agonist or an antagonist towards biological activity.Moreover, Thornber applied the term bioisosterism to include subunits, groups or molecules that possess physicochemical properties of similar biological effects [6]. Finally, in 1991 Burger widened the definition of bioisosteres to include compounds or groups that possess similar molecular shapes and volumes independent of agonists or antagonists [7]. REVIEW ARTICLE Squaryl KitsonThese bioisosteres would require approximately the same distribution of electrons and give a high probability of generating comparable physical properties such as hydrophobicity [8]. Currently, bioisosterism is one of the most useful tools to the medicinal chemist in rational drug design and in particular regarding the carboxylic acid bioisosteres [9]. The carboxylic acid functional ...

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“…X-ray tomography provides volumetric information about the body or a particular organ. When used in conjunction with the injection of a contrast agent and with an appropriate data analysis, it enables, for example, efficient cardiovascular, pulmonary, and tumor imaging [28][29][30].…”

Section: Molecular Diagnostics As a Driver For Systems Medicinementioning

confidence: 99%

Future of Medicine: Models in Predictive Diagnostics and Personalized Medicine

Regierer

Zazzu

Sudbrak

et al. 2013

Advances in Biochemical Engineering/Biotechnology

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Molecular medicine is undergoing fundamental changes driving the whole area towards a revolution in modern medicine. The breakthrough was generated the fast-developing technologies in molecular biology since the first draft sequence of the human genome was published. The technological advances enabled the analysis of biological samples from cells and organs to whole organisms in a depth that was not possible before. These technologies are increasingly implemented in the medical and health care system to study diseases and refine diagnostics. As a consequence, the understanding of diseases and the health status of an individual patient is now based on an enormous amount of data that can only be interpreted in the context of the body as a whole. Systems biology as a new field in the life sciences develops new approaches for data integration and interpretation. Systems medicine as a specialized aspect of systems biology combines in an interdisciplinary approach all expertise necessary to decipher the human body in all its complexity. This created new challenges in the area of information and communication technologies to provide the infrastructure and technology needed to cope with the data flood that will accompany the next generation of medicine. The new initiative 'IT Future of Medicine' aims at driving this development even further and integrates not only molecular data (especially genomic information), but also anatomical, physiological, environmental, and lifestyle data in a predictive model approach-the 'virtual patient'-that will allow the clinician or the general practitioner to predict and anticipate the optimal treatment for the individual patient. The application of the virtual patient model will allow truly personalized medicine.

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Advances in multimodality molecular imaging

Cited by 43 publications

References 30 publications

Multifunctional Probes for Multimodality Imaging of Cancer

Multifunctional Probes for Multimodality Imaging of Cancer

Squaryl Molecular Metaphors – Application to Rational Drug Design and Imaging Agents

Future of Medicine: Models in Predictive Diagnostics and Personalized Medicine

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