Advances in Nanotechnology-Based Drug Delivery in Targeting PI3K Signaling in Respiratory Diseases

Chan, Yinghan; MacLoughlin, Ronan; Zacconi, Flavia; Tambuwala, Murtaza M.; Pabari, Ritesh M.; Singh, Sachin Kumar; Pinto, Terezinha de Jesus Andreoli; Gupta, Gaurav; Chellappan, Dinesh Kumar; Dua, Kamal

doi:10.2217/nnm-2021-0087

Cited by 6 publications

(1 citation statement)

References 20 publications

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“…In contrast to free nimbolide, iRGD-NIML ip also suppressed oxidative stress and cytokine storm. Consequently, these findings suggest that advanced drug delivery systems can be used as novel therapeutics for COVID-19 and other chronic respiratory diseases ( 48 , 63 ). In addition, nimbolide displayed inhibitory effect on autophagy in an in vivo fibrosis model ( 64 ).…”

Section: Anti-inflammatory Effect Of Nimbolide In Respiratory Diseasesmentioning

confidence: 99%

Nimbolide: promising agent for prevention and treatment of chronic diseases (recent update)

Rajendran,

Renu,

Abdallah

et al. 2024

Food & Nutrition Research

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Background: Nimbolide, a bioactive compound derived from the neem tree, has garnered attention as a potential breakthrough in the prevention and treatment of chronic diseases. Recent updates in research highlight its multifaceted pharmacological properties, demonstrating anti-inflammatory, antioxidant, and anticancer effects. With a rich history in traditional medicine, nimbolide efficacy in addressing the molecular complexities of conditions such as cardiovascular diseases, diabetes, and cancer positions it as a promising candidate for further exploration. As studies progress, the recent update underscores the growing optimism surrounding nimbolide as a valuable tool in the ongoing pursuit of innovative therapeutic strategies for chronic diseases. Methods: The comprehensive search of the literature was done until September 2020 on the MEDLINE, Embase, Scopus and Web of Knowledge databases. Results: Most studies have shown the Nimbolide is one of the most potent limonoids derived from the flowers and leaves of neem (Azadirachta indica), which is widely used to treat a variety of human diseases. In chronic diseases, nimbolide reported to modulate the key signaling pathways, such as Mitogen-activated protein kinases (MAPKs), Wingless-related integration site-β (Wnt-β)/catenin, NF-κB, PI3K/AKT, and signaling molecules, such as transforming growth factor (TGF-β), Matrix metalloproteinases (MMPs), Vascular Endothelial Growth Factor (VEGF), inflammatory cytokines, and epithelial-mesenchymal transition (EMT) proteins. Nimbolide has anti-inflammatory, anti-microbial, and anti-cancer properties, which make it an intriguing compound for research. Nimbolide demonstrated therapeutic potential for osteoarthritis, rheumatoid arthritis, cardiovascular, inflammation and cancer. Conclusion: The current review mainly focused on understanding the molecular mechanisms underlying the therapecutic effects of nimbolide in chronic diseases.

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Section: Anti-inflammatory Effect Of Nimbolide In Respiratory Diseasesmentioning

confidence: 99%