Advances in novel parentral drug delivery systems

Abstract

T he parenteral administration route is the most effective and common form of delivery for active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. Drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in terms of compliance, but also to improve the quality of the therapy. Such reduction in frequency of drug dosing is achieved by the use of specific formulation technologies that guarantee the release of the active drug substance in a slow and predictable manner. The development of new injectable drug delivery system has received considerable attention over the past few years. A number of technological advances have been made in the area of parenteral drug delivery leading to the development of sophisticated systems that allow drug targeting and the sustained or controlled release of parenteral medicines.

Nanoemulsions — Advances in Formulation, Characterization and Applications in Drug Delivery

“…Major clinical and pre-clinical trials have hence been carried out with parenteral nanoemulsion based carriers. The advances in these novel drug delivery systems have been reviewed by Patel and Patel [162]. Nanoemulsions loaded with thalidomide have been synthesized where a dose as low as 25 mg leads to plasma concentrations which can be therapeutic [163].…”

Validated HPLC and stability-indicating densitometric chromatographic methods for simultaneous determination of camylofin dihydrochloride and paracetamol in their binary mixture

“…The spectrum of camylofin-2HCl shows signals at 3.5, 1.4, 1.2 and 0.73 ppm for H of two methylene groups located between 2 amino groups (2), H of two methylene of tertiary amines (3), H of methyl groups (4) and H of (O-CH 2 -CH 2 ) (5), respectively, which completely disappear in the 1 HMNR spectrum of the degradate. 1 HMNR spectrum of camylofin-2HCl shows a signal at 3.4 ppm, which completely disappears in D 2 O spectrum, which represents H for secondary amino group (6), while at degradate, the spectrum shows a signal at (7).…”

“…It is found in market as single or combined formulation with paracetamol, nimesulide, diclofenac and analgin. The literature revealed many analytical techniques for the quantification of camylofin-2HCl such as spectrophotometry [3,4], HPLC [5][6][7][8][9] TLC densitometry [6,7,[10][11][12] and GC [13,14].…”

An Update on Nanoemulsions Using Nanosized Liquid in Liquid Colloidal Systems

“…Nanoemulsions loaded with thalidomide have been synthesized. A dose as low as 25 mg leads to plasma concentrations which can be therapeutic when delivered through this system [34].…”