Advances in ophthalmic drug delivery

Singh, Thakur Raghu Raj; Jones, David S.

doi:10.1111/jphp.12249

Journal of Pharmacy and Pharmacology

2014

DOI: 10.1111/jphp.12249

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Advances in ophthalmic drug delivery

Thakur Raghu Raj Singh

David S. Jones

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Cited by 11 publications

References 8 publications

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Lignin‐Containing Self‐Nanoemulsifying Drug Delivery System for Enhance Stability and Oral Absorption of trans‐Resveratrol

Dai

Zhu

et al. 2018

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Self‐nanoemulsifying drug delivery system (SNEDDS) is recently studied for enhancing the bioavailability of hydrophobic drugs, such as resveratrol (RSV). However, the functional design of SNEDDS for the drug structural protection is not studied yet. Here, this paper presents an efficient approach by adding lignin (a kind of abundant biomass resource) to enhance the stability of trans‐RSV and meantime improve its oral bioavailability. Higher stability of trans‐RSV (just decreased 2% to cis‐RSV after 1 h under direct sunlight) is observed after loaded by lignin‐containing SNEDDS (RSV/SLS SNEDDS). Low toxicity, high transfer efficiency (apparent permeability coefficient >1 × 10−7 cm s−1), and bioavailability (1.371%) of RSV/SLS SNEDDS is successfully demonstrated in Caco‐2 cells and rat model, respectively. This study serves to illustrate a simple, versatile, environmental, and economic sustainability approach to the development of nanodelivery systems for light instability drugs.

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Lignin‐Containing Self‐Nanoemulsifying Drug Delivery System for Enhance Stability and Oral Absorption of trans‐Resveratrol

Dai

Zhu

et al. 2018

Part & Part Syst Charact

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In situ forming phase-inversion implants for sustained ocular delivery of triamcinolone acetonide

Sheshala

Hong

Yee

et al. 2018

Drug Deliv. and Transl. Res.

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The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepared formulations. TA (at 0.5%, 1% and 2.5% w/w loading) was dissolved in N-methyl-2-pyrrolidone (NMP) solvent and then incorporated 30% w/w PLGA (50/50 and 75/25) polymer to prepare homogenous injectable solution. The formulations were evaluated for rheological behaviour using rheometer, syringeability by texture analyser, water uptake and rate of implant formation by optical coherence tomography (OCT) microscope. Phase inversion in situ forming formulations were injected into PBS pH 7.3 to form an implant and release samples were collected and analysed for drug content using a HPLC method. All formulations exhibited good syringeability and rheological properties (viscosity: 0.19-3.06 Pa.s) by showing shear thinning behaviour which enable them to remain as free-flowing solution for ease administration. The results from OCT microscope demonstrated that thickness of the implants were increased with the increase in time and the rate of implant formation indicated the fast phase inversion. The drug release from implants was sustained over a period of 42 days. The research findings demonstrated that PLGA/NMP-based phase inversion in situ forming implants can improve compliance in patient's suffering from ocular diseases by sustaining the drug release for a prolonged period of time and thereby reducing the frequency of ocular injections.

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Nanotherapies for the treatment of ocular diseases

Reimondez-Troitiño

Csaba

Alonso

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

153

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Advances in ophthalmic drug delivery

Cited by 11 publications

References 8 publications

Lignin‐Containing Self‐Nanoemulsifying Drug Delivery System for Enhance Stability and Oral Absorption of trans‐Resveratrol

Lignin‐Containing Self‐Nanoemulsifying Drug Delivery System for Enhance Stability and Oral Absorption of trans‐Resveratrol

In situ forming phase-inversion implants for sustained ocular delivery of triamcinolone acetonide

Nanotherapies for the treatment of ocular diseases

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