Advances in optical coherence tomography in dermatology—a review

Olsen, Jørgen; Holmes, Jon; Jemec, Gregor B. E.

doi:10.1117/1.jbo.23.4.040901

Cited by 124 publications

(98 citation statements)

References 108 publications

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“…Originally developed for ophthalmic applications to image the posterior segment of the eye [3,[33][34][35] and further enhanced with OCT angiography [36,37], OCT has found successful applications in the anterior segment of the eye [30], as well as in a number of fields, including dermatology [38,39], oncology [40][41][42][43][44][45][46] and dentistry [47]; in endoscopic form it has been applied to cardiology [48,49], gastroenterology [50,51], and pulmonology [52][53][54]. Numerous embodiments of functional OCT [55], including Doppler OCT and polarization-sensitive OCT [56,57], as well as optical coherence elastography [58][59][60][61][62][63][64], multimodal fluorescence-OCT [2,[65][66][67] and spectroscopic OCT [68], have been developed to enhance the structural information obtained with OCT with properties related to tissue function.…”

Section: Applicationsmentioning

confidence: 99%

Ten Years of Gabor-Domain Optical Coherence Microscopy

Canavesi

Rolland

2019

Applied Sciences

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Gabor-domain optical coherence microscopy (GDOCM) is a high-definition imaging technique leveraging principles of low-coherence interferometry, liquid lens technology, high-speed imaging, and precision scanning. GDOCM achieves isotropic 2 μm resolution in 3D, effectively breaking the cellular resolution limit of optical coherence tomography (OCT). In the ten years since its introduction, GDOCM has been used for cellular imaging in 3D in a number of clinical applications, including dermatology, oncology and ophthalmology, as well as to characterize materials in industrial applications. Future developments will enhance the structural imaging capability of GDOCM by adding functional modalities, such as fluorescence and elastography, by estimating thicknesses on the nano-scale, and by incorporating machine learning techniques.

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Section: Applicationsmentioning

confidence: 99%

Ten Years of Gabor-Domain Optical Coherence Microscopy

Canavesi

Rolland

2019

Applied Sciences

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“…A promising field of application for OCT is in dermatology, where it has two distinct virtues: whereas dermatoscopy provides a high‐resolution en face view of the skin surface, OCT offers cross‐sectional imaging revealing tissue morphology down to a depth of 1 to 2 millimeters. In addition, compared with the gold standard histology, non‐invasiveness of OCT allows repeated imaging sessions to monitor pathogenesis and therapy over time without the need of taking tissue samples . Recently, it has been proved that OCT can be used in the diagnosis of BCC .…”

Section: Introductionmentioning

confidence: 99%

Automatic skin lesion area determination of basal cell carcinoma using optical coherence tomography angiography and a skeletonization approach: Preliminary results

Meiburger

Chen

Sinz

et al. 2019

Journal of Biophotonics

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Cutaneous blood flow plays a key role in numerous physiological and pathological processes and has significant potential to be used as a biomarker to diagnose skin diseases such as basal cell carcinoma (BCC). The determination of the lesion area and vascular parameters within it, such as vessel density, is essential for diagnosis, surgical treatment and follow‐up procedures. Here, an automatic skin lesion area determination algorithm based on optical coherence tomography angiography (OCTA) images is presented for the first time. The blood vessels are segmented within the OCTA images and then skeletonized. Subsequently, the skeleton is searched over the volume and numerous quantitative vascular parameters are calculated. The vascular density is then used to segment the lesion area. The algorithm is tested on both nodular and superficial BCC, and comparing with dermatological and histological results, the proposed method provides an accurate, non‐invasive, quantitative and automatic tool for BCC lesion area determination.

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“…Optical coherence tomography (OCT) is an optical imaging technique, which was introduced in the early 1990s [25] and has since become a standard diagnostic tool in ophthalmology [26]. OCT has also been used in many other fields including dermatology, endoscopy and neuroimaging [27][28][29]. OCT data can be acquired in three-dimensional (3D), in real time, and with micrometer resolution [25].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography

et al. 2019

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One key hallmark of Alzheimer’s disease (AD) is the accumulation of extracellular amyloid-beta protein in cortical regions of the brain. For a definitive diagnosis of AD, post-mortem histological analysis, including sectioning and staining of different brain regions, is required. Here, we present optical coherence tomography (OCT) as a tissue-preserving imaging modality for the visualization of amyloid-beta plaques and compare their contrast in intensity- and polarization-sensitive (PS) OCT. Human brain samples of eleven patients diagnosed with AD were imaged. Three-dimensional PS-OCT datasets were acquired and plaques were manually segmented in 500 intensity and retardation cross-sections per patient using the freely available ITK-SNAP software. The image contrast of plaques was quantified. Histological staining of tissue sections from the same specimens was performed to compare OCT findings against the gold standard. Furthermore, the distribution of plaques was evaluated for intensity-based OCT, PS-OCT and the corresponding histological amyloid-beta staining. Only 5% of plaques were visible in both intensity and retardation segmentations, suggesting that different types of plaques may be visualized by the two OCT contrast channels. Our results indicate that multicontrast OCT imaging might be a promising approach for a tissue-preserving visualization of amyloid-beta plaques in AD.

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Advances in optical coherence tomography in dermatology—a review

Cited by 124 publications

References 108 publications

Ten Years of Gabor-Domain Optical Coherence Microscopy

Ten Years of Gabor-Domain Optical Coherence Microscopy

Automatic skin lesion area determination of basal cell carcinoma using optical coherence tomography angiography and a skeletonization approach: Preliminary results

Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography

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