Advances in Pathogenesis of Behcet’s Disease and Vogt- Koyanagi-Harada Syndrome

Yang, Peizeng; Wang, Chaokui; Hou, Shengping; Lei, Bo; Kijlstra, Aize; Li, Dequan

doi:10.5772/57586

Cited by 3 publications

(2 citation statements)

References 165 publications

(130 reference statements)

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“…38] and central involvement of IL-1 in pathogenesis. However, this could be an artificial separation that reflects etiology more than pathology, because even in diseases now thought of as auto-inflammatory, including Behcet’s uveitis, there are demonstrable responses to ocular antigens [39] whereas other studies report evidence for enhanced Th1 and Th17 responses (although it is not known whether the two are connected) [40, 41]. Therefore, irrespective of the initial trigger, autoimmune responses to retinal Ags released as a result of tissue breakdown may become drivers of disease.…”

Section: Uveitis: Inflammation Characterized By the Involvement Of Admentioning

confidence: 99%

Immune mechanisms in inflammatory and degenerative eye disease

Pérez

Caspi

2015

Trends in Immunology

161

151

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It has recently been recognized that pathology of age-associated degenerative eye diseases such as adult macular degeneration (AMD), glaucoma and diabetic retinopathy, have strong immunological underpinnings. Attempts have been made to extrapolate to age-related degenerative disease insights from inflammatory processes associated with non-infectious uveitis, but these have not yet been sufficiently informative. Here we review recent findings on the immune processes underlying uveitis and those that have been shown to contribute to AMD, discussing in this context parallels and differences between overt inflammation and para-inflammation in the eye. We propose that mechanisms associated with ocular immune privilege, in combination with paucity of age-related antigen(s) within the target tissue, dampen what could otherwise be overt inflammation and result in the para-inflammation that characterizes age-associated neurodegenerative disease.

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Section: Uveitis: Inflammation Characterized By the Involvement Of Admentioning

confidence: 99%

Immune mechanisms in inflammatory and degenerative eye disease

Pérez

Caspi

2015

Trends in Immunology

161

151

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“…To date, there are few studies on DEX treatment in refractory uveitic ME. To the best of our knowledge, this is the first real-world study in Taiwan, where the etiology of uveitis is different from that in Western countries, with a higher incidence of juvenile idiopathic arthritis [16], Vogt-Koyanagi-Harada syndrome, and Behcet's disease [18]. Although some of our findings have been reported previously, the effect of dexamethasone in refractory uveitic ME has not been well investigated in Asian populations, which may have a different response to steroid treatment.…”

Section: Discussionmentioning

confidence: 91%

Intravitreal Dexamethasone Implants for Refractory Macular Edema in Eyes with Noninfectious Uveitis

Kang

Chen

et al. 2021

JCM

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Macular edema (ME) is a common cause of visual loss among eyes with uveitis, and its management can be challenging. Steroids are an effective treatment for ME, and intravitreal dexamethasone (DEX) implants provide sustained steroid release. The purpose of this study is to evaluate intravitreal DEX implant on refractory ME in eyes with noninfectious uveitis. A retrospective study including 52 eyes of 37 patients with refractory uveitic ME was conducted from January 2011 through August 2017 at Linkou Chang Gung Memorial Hospital in Taiwan. Patients’ demographic characteristics were collected. In addition, clinical information, including corrected visual acuity (VA), intraocular pressure (IOP), and central retinal thickness (CRT) on optical coherence tomography, was recorded and analyzed. During the study period, affected eyes received a total of 110 intravitreal DEX implants (range, one to six in each eye). After the first DEX implant injection in all eyes, VA significantly improved at one and two months. CRT significantly decreased one month after a single DEX implant, and the effect lasted for six months and waned over time. Patients receiving multiple DEX implants still showed significant decreases in CRT one month after the first implant. Increases in IOP were noted one month after the DEX implant, but the IOP could be medically controlled. Intravitreal DEX implants can effectively treat refractory uveitic ME, improving both VA and CRT with an acceptable safety profile. Further studies are necessary to evaluate the effect of multiple implants and long-term outcomes.

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Correlation between IL-17A/F, IL-23, IL-35 and IL-12/-23 (p40) levels in peripheral blood lymphocyte cultures and disease activity in Behcet’s patients

et al. 2018

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Behcet's disease is a chronic multisystemic disease with remissions and relapses. Several studies have shown that immune mechanisms play an important role in the development of the disease. In order to assess the association of disease activity with IL-17A/F, IL-23, IL-12/23 (p40) and IL-35 expression, we aimed to investigate production of these cytokines in peripheral blood mononuclear cells (PBMCs) from Behcet's patients and normal controls. Furthermore, we included Systemic Lupus Erythematosus (SLE) as disease control to evaluate the specificity of our data for immunopathogenesis of BD. Totally 15 active, 15 inactive Behcet's patients, 12 active and 12 inactive SLE patients and 12 healthy volunteers were enrolled in the study. Peripheral blood mononuclear cells were separated, lymphocyte cultures were performed and IL-17A/F, IL-12/23 p(40), IL-23, IL-35 cytokine levels were measured by ELISA in culture supernatants in the presence or absence of phytohemagglutinin (PHA) on time-dependent manner. IL-17 A/F levels increased parallel to IL-23 levels in Behcet's and SLE patients. Compared to healthy controls, IL-17 A/F levels were higher in active Behcet's and SLE patients; on the contrary, levels of IL-35 were lower. IL-17A/F, IL-12/23 (p40) and IL-23 levels were detectable most frequently in active Behcet's patients followed by active SLE patients. Our results indicate that IL-17 A/F, IL-23 and IL-12/23 (p40) may play role in the immunopathogenesis of BD so as Th17 and Th1 cell responses. Since IL-35 levels were lower in active Behcet's patients compared to inactive patients and healthy controls, there may be a plasticity between Th17 and Treg cells according to the state of disease activity.

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Advances in Pathogenesis of Behcet’s Disease and Vogt- Koyanagi-Harada Syndrome

Cited by 3 publications

References 165 publications

Immune mechanisms in inflammatory and degenerative eye disease

Immune mechanisms in inflammatory and degenerative eye disease

Intravitreal Dexamethasone Implants for Refractory Macular Edema in Eyes with Noninfectious Uveitis

Correlation between IL-17A/F, IL-23, IL-35 and IL-12/-23 (p40) levels in peripheral blood lymphocyte cultures and disease activity in Behcet’s patients

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