Advances in Pinhole and Multi-Pinhole Collimators For Single Photon Emission Computed Tomography Imaging

Islamian, Jalil Pirayesh; Azazrm, AhmadReza; Moeini, Babak; Gharapapagh, Esmail

doi:10.4103/1450-1147.150505

Cited by 21 publications

(8 citation statements)

References 57 publications

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“…The results for the 2DT-Scanner in our work are largely consistent with earlier studies on the performance of its established predecessor U-SPECT-II [10]. The tested scanner maintains the characteristic advantages and disadvantages of ultra-high-resolution multi-pinhole SPECT with stationary detectors compared to opponents with moving detectors [3,[21][22][23].…”

Section: Discussionsupporting

confidence: 88%

Performance Evaluation of Fifth-Generation Ultra-High-Resolution SPECT System with Two Stationary Detectors and Multi-Pinhole Imaging

Hoffmann

Janssen

Kuriyama

et al. 2020

Preprint

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Background: Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector-configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+).Methods: The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Results: Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. In the visually analysed sections of the reconstructed mini Derenzo phantom, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60-1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR.Conclusions: While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.

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Section: Discussionsupporting

confidence: 88%

Performance Evaluation of Fifth-Generation Ultra-High-Resolution SPECT System with Two Stationary Detectors and Multi-Pinhole Imaging

Hoffmann

Janssen

Kuriyama

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…XUHR-M may be suitable for overnight scans of dead animals with high injection dose and high uptake values in the target organ.The results for the 2DT-Scanner in our work are largely consistent with earlier studies on the performance of its established predecessor U-SPECT-II[10]. The tested scanner maintains the characteristic advantages and disadvantages of ultra-high-resolution multi-pinhole SPECT with stationary detectors compared to opponents with moving detectors[3,[21][22][23].…”

supporting

confidence: 88%

Performance Evaluation of Fifth-generation Ultra-high-resolution Spect System With Two Stationary Detectors and Multi-pinhole Imaging

Hoffmann

Janssen

Kuriyama

et al. 2020

Preprint

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Purpose Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector-configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+). Methods The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Results Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. Resolution in the visually analysed sections of the reconstructed hot-rod phantom was 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M). Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60–1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR. Conclusions While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.

show abstract

“…The results for the 2DT-Scanner in our work are largely consistent with earlier studies on the performance of its established predecessor U-SPECT-II [ 10 ]. The tested scanner maintains the characteristic advantages and disadvantages of ultra-high-resolution multi-pinhole SPECT with stationary detectors compared to opponents with moving detectors [ 3 , 21 – 23 ].…”

Section: Discussionmentioning

confidence: 99%

Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging

et al. 2020

View full text Add to dashboard Cite

Background Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+). Methods The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Results Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. In the visually analysed sections of the reconstructed mini Derenzo phantoms, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60 to 1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR. Conclusions While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.

show abstract

Advances in Pinhole and Multi-Pinhole Collimators For Single Photon Emission Computed Tomography Imaging

Cited by 21 publications

References 57 publications

Performance Evaluation of Fifth-Generation Ultra-High-Resolution SPECT System with Two Stationary Detectors and Multi-Pinhole Imaging

Performance Evaluation of Fifth-Generation Ultra-High-Resolution SPECT System with Two Stationary Detectors and Multi-Pinhole Imaging

Performance Evaluation of Fifth-generation Ultra-high-resolution Spect System With Two Stationary Detectors and Multi-pinhole Imaging

Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging

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