Advances in Plants-Derived Bioactives for Cancer Treatment

Cruz‐Martins, Natália

doi:10.3390/cells12081112

Cited by 3 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Genetic mutations often lead to increased drug resistance in tumor cells, making existing treatment methods ineffective in controlling tumor growth and spread ( Qunaj et al, 2023 ). Therefore, researchers have been searching for new treatment strategies to overcome this challenge ( Cruz-Martins, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Magnetic propelled hydrogel microrobots for actively enhancing the efficiency of lycorine hydrochloride to suppress colorectal cancer

Jiang,

Zheng,

Zhao

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Research and development in the field of micro/nano-robots have made significant progress in the past, especially in the field of clinical medicine, where further research may lead to many revolutionary achievements. Through the research and experiment of microrobots, a controllable drug delivery system will be realized, which will solve many problems in drug treatment. In this work, we design and study the ability of magnetic-driven hydrogel microrobots to carry Lycorine hydrochloride (LH) to inhibit colorectal cancer (CRC) cells. We have successfully designed a magnetic field driven, biocompatible drug carrying hydrogel microsphere robot with Fe3O4 particles inside, which can achieve magnetic field response, and confirmed that it can transport drug through fluorescence microscope. We have successfully demonstrated the motion mode of hydrogel microrobots driven by a rotating external magnetic field. This driving method allows the microrobots to move in a precise and controllable manner, providing tremendous potential for their use in various applications. Finally, we selected drug LH and loaded it into the hydrogel microrobot for a series of experiments. LH significantly inhibited CRC cells proliferation in a dose- and time-dependent manner. LH inhibited the proliferation, mobility of CRC cells and induced apoptosis. This delivery system can significantly improve the therapeutic effect of drugs on tumors.

show abstract

Section: Introductionmentioning

confidence: 99%

Magnetic propelled hydrogel microrobots for actively enhancing the efficiency of lycorine hydrochloride to suppress colorectal cancer

Jiang,

Zheng,

Zhao

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Traditional medicines frequently employ them in the custom of homemade tinctures, teas, or crude extracts. Several active constituents isolated from herbs such as Curcuma longa, Fagonia indica, Garcinia olongifolia, Hedyotis diffusa, Morus alba, Perilla frutescens, and Tripterygium wilfordii have been reported to possess anticancer properties ( Cruz-Martins, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Development of topical silver nano gel formulation of Bixin: Characterization, and evaluation of anticancer activity

Patil,

khulbe,

Nitalikar

et al. 2024

Saudi Pharmaceutical Journal

View full text Add to dashboard Cite

Polyphenol Contents, Antibacterial and Antioxidant Effects of Four Palestinian Honey Samples, and their Anticancer Effects on Human Breast Cancer Cells

Abu-Farich,

Hamarshi,

Masalha

et al. 2024

J. Pure Appl. Microbiol.

View full text Add to dashboard Cite

The phenolic compounds of four Palestinian honey samples (PH1-PH4) and their antibacterial effects as well as their cytotoxic, cytostatic, and antimigration effects in human breast cancer cell line (MDA) were evaluated here. HPLC analysis of PH2 (Cornflower), PH3 (Milk thistle), and PH4 (Ziziphus) revealed 15 phenolic compounds, namely, caffeic acid, carvacrol, chrysin, ellagic acid, galangin, gallic acid, kaempferol, p-coumaric acid, pinobanksin, pinocembrin, protocatechuic acid, quercetin, rutin, salicylic acid, and silydamin. The minimum inhibitory concentration (MIC) method applied to Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli). A strong positive correlation was detected between antimicrobial activity (E. coli) and p-coumaric acid, quercetin, and silydamin. IC50 values for DPPH neutralization varied from 0.19 w/w% to 10 w/w%. The potential anticancer properties of the honey samples were evaluated on MDA cells. Samples PH2 and PH3 demonstrated cytostatic activity, reducing cell viability by about 43% at non-toxic concentration of 4 mg/mL. The cytostatic effects were strongly correlated with the presence of caffeic acid, chrysin, protocatechuic acid, rutin, and salicylic acid (p < 0.01). Moreover, the cell migration rate was significantly reduced (by up to 85%) with PH2 and PH3 compared to untreated cells (p < 0.05). A strong positive correlation was observed between the cytostatic effects of the concentration of carvacrol and Pinocembrin (p < 0.01). Our findings validate honey’s antibacterial properties and suggest its anticancer benefits may stem from cytostatic and antimigration effects.

show abstract

Advances in Plants-Derived Bioactives for Cancer Treatment

Cited by 3 publications

References 18 publications

Magnetic propelled hydrogel microrobots for actively enhancing the efficiency of lycorine hydrochloride to suppress colorectal cancer

Magnetic propelled hydrogel microrobots for actively enhancing the efficiency of lycorine hydrochloride to suppress colorectal cancer

Development of topical silver nano gel formulation of Bixin: Characterization, and evaluation of anticancer activity

Polyphenol Contents, Antibacterial and Antioxidant Effects of Four Palestinian Honey Samples, and their Anticancer Effects on Human Breast Cancer Cells

Contact Info

Product

Resources

About