Advances in point-of-care optical biosensing for underserved populations

Chaturvedi, Nandita; Goncharov, Artem; Tripathy, Sayantan; San Juan, Angela Michelle T.; Mabbott, Samuel B.; Ozcan, Aydogan; Ligler, Frances S.; Coté, Gerard L.

doi:10.1016/j.trac.2024.117731

Cited by 1 publication

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“…Thus there is a real need for more sophisticated analytical biosensors that can provide increased sensitivity and specificity and test for multiple targets simultaneously. Low cost devices that can diagnose multiple diseases simultaneously have been under commercialization for over 20 years [15] and being continuously improved [5,16,17].…”

Section: Current Optical Biosensor Configurationsmentioning

confidence: 99%

Forty years of advances in optical biosensors—are “autonomous” biosensors in our future?

Ligler,

Ligler

2024

Anal Bioanal Chem

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Optical biosensors have employed at least three distinct system architectures over the last 40 years, moving from “sample in-answer out” systems to completely embedding the optical biosensor into the sample to embedding the recognition module in the sample and optically interrogating the recognition module from outside of the sample. This trends article provides an overview of the evolution of these three system architectures and discusses how each architecture has been applied to solve the measurement challenges of a wide variety of applications. A fourth biosensor system architecture, that of an “autonomous” biosensor which “takes the user out of the loop” while both detecting target analytes and responding to that measurement, is currently under development for applications initially including environmental cleanup and “smart therapeutics.” As is the case in many other areas of technology, it will be profoundly interesting to observe the further development and application of elegant, simpler (optical) biosensor systems to address tomorrow’s measurement needs. Graphical abstract

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