Advances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and Challenges

Prakash, Priyanka; Lee, Wing-Hin; Loo, Ching-Yee; Wong, Hau Seung Jeremy; Parumasivam, Thaigarajan

doi:10.3390/nano12010175

Cited by 42 publications

(32 citation statements)

References 140 publications

(165 reference statements)

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“…PHA granules made this way are tunable (for chemical composition, size, or other key qualities) to levels not possible with chemical synthesis, genetically altering the bacterial strain or adjusting the production circumstances such as the culture media composition. The crux of interest that lies in PHA NPs is their self-assembling properties, their production using easily cultivated bacterial species, and the different morphological types of particles [ 315 ].…”

Section: Biologically Synthesized Biodegradable Polyhydroxyalkanoate-...mentioning

confidence: 99%

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

et al. 2022

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Nanoparticles (NPs) have remarkable properties for delivering therapeutic drugs to the body’s targeted cells. NPs have shown to be significantly more efficient as drug delivery carriers than micron-sized particles, which are quickly eliminated by the immune system. Biopolymer-based polymeric nanoparticles (PNPs) are colloidal systems composed of either natural or synthetic polymers and can be synthesized by the direct polymerization of monomers (e.g., emulsion polymerization, surfactant-free emulsion polymerization, mini-emulsion polymerization, micro-emulsion polymerization, and microbial polymerization) or by the dispersion of preformed polymers (e.g., nanoprecipitation, emulsification solvent evaporation, emulsification solvent diffusion, and salting-out). The desired characteristics of NPs and their target applications are determining factors in the choice of method used for their production. This review article aims to shed light on the different methods employed for the production of PNPs and to discuss the effect of experimental parameters on the physicochemical properties of PNPs. Thus, this review highlights specific properties of PNPs that can be tailored to be employed as drug carriers, especially in hospitals for point-of-care diagnostics for targeted therapies.

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Section: Biologically Synthesized Biodegradable Polyhydroxyalkanoate-...mentioning

confidence: 99%

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

et al. 2022

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“…In the last decade, PHAs have drawn substantial interest for tissue engineering and as biomaterials for scaffolds, due to their thermal and mechanical properties, as well as biocompatibility and biodegradability, and feasibility to blend with other polymers to form copolymers [ 28 , 29 , 30 , 31 , 32 ]. The U.S. Food and Drug Administration (FDA) has approved PHAs for several biomedical applications [ 28 , 31 ].…”

Section: Common Types Of Pha Used In Tissue Repair and Engineeringmentioning

confidence: 99%

“…The U.S. Food and Drug Administration (FDA) has approved PHAs for several biomedical applications [ 28 , 31 ]. Hence, the polymer has been widely investigated for artificial cartilages, dressing of wounds, artificial vessels, tendon healing, tubular substitutes, heart valves, bone grafts and stents for nerve repair [ 28 , 29 , 30 , 31 , 32 , 33 , 34 ], as summarized in Table 1 . In fact, up to date, the US FDA has approved a number of PHA-based products, including TephaFLEX ® (sutures made of poly (4-hydroxybutyrate), P(4HB)) [ 31 , 35 ], Phasix TM (mesh made from P(4HB) for the treatment of hernia) [ 31 , 36 ] and Monomax ® (sutures made of P(4HB)) [ 31 , 37 ].…”

Section: Common Types Of Pha Used In Tissue Repair and Engineeringmentioning

confidence: 99%

Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering

et al. 2022

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Tissue engineering technology aids in the regeneration of new tissue to replace damaged or wounded tissue. Three-dimensional biodegradable and porous scaffolds are often utilized in this area to mimic the structure and function of the extracellular matrix. Scaffold material and design are significant areas of biomaterial research and the most favorable material for seeding of in vitro and in vivo cells. Polyhydroxyalkanoates (PHAs) are biopolyesters (thermoplastic) that are appropriate for this application due to their biodegradability, thermo-processability, enhanced biocompatibility, mechanical properties, non-toxicity, and environmental origin. Additionally, they offer enormous potential for modification through biological, chemical and physical alteration, including blending with various other materials. PHAs are produced by bacterial fermentation under nutrient-limiting circumstances and have been reported to offer new perspectives for devices in biological applications. The present review discusses PHAs in the applications of conventional medical devices, especially for soft tissue (sutures, wound dressings, cardiac patches and blood vessels) and hard tissue (bone and cartilage scaffolds) regeneration applications. The paper also addresses a recent advance highlighting the usage of PHAs in implantable devices, such as heart valves, stents, nerve guidance conduits and nanoparticles, including drug delivery. This review summarizes the in vivo and in vitro biodegradability of PHAs and conducts an overview of current scientific research and achievements in the development of PHAs in the biomedical sector. In the future, PHAs may replace synthetic plastics as the material of choice for medical researchers and practitioners.

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“…On the other hand, the fungicidal action of 10-undecenoic acid has been the subject of research [19][20][21] because it is a very accessible compound [22][23][24] but also because it can be administered in various ways (creams, ointments, sprays or oxide dispersions) [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

et al. 2022

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The bio-medical benefits of silver ions and 10–undecenoic acid in various chemical-pharmaceutical preparations are indisputable, thus justifying numerous research studies on delayed and/or controlled release. This paper presents the effect of the polymer matrix in the simultaneous release of silver ions and 10–undecenoic acid in an aqueous medium of controlled pH and ionic strength. The study took into consideration polymeric matrices consisting of cellulose acetate (CA) and polysulfone (PSf), which were impregnated with oxide nanoparticles containing silver and 10–undecenoic acid. The studied oxide nanoparticles are nanoparticles of iron and silver oxides obtained by an accessible electrochemical method. The obtained results show that silver can be released, simultaneously with 10–undecenoic acid, from an impregnated polymeric membrane, at concentrations that ensure the biocidal and fungicidal capacity. Concentrations of active substances can be controlled by choosing the polymer matrix or, in some cases, by changing the pH of the target medium. In the studied case, higher concentrations of silver ions are released from the polysulfone matrix, while higher concentrations of 10–undecenoic acid are released from the cellulose acetate matrix. The results of the study show that a correlation can be established between the two released target substances, which is dependent on the solubility of the organic compound in the aqueous medium and the interaction of this compound with the silver ions. The ability of 10–undecenoic acid to interact with the silver ion, both through the carboxyl and alkene groups, contributes to the increase in the content of the silver ions transported in the aqueous medium.

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Advances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and Challenges

Cited by 42 publications

References 140 publications

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles

Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

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